Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice
Abstract Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by homophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for e...
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Nature Portfolio
2018
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oai:doaj.org-article:76dd807a63434fb9810b1cdb6dd57bdf2021-12-02T11:41:15ZMolecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice10.1038/s41598-018-28034-42045-2322https://doaj.org/article/76dd807a63434fb9810b1cdb6dd57bdf2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28034-4https://doaj.org/toc/2045-2322Abstract Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by homophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory.Tatsuya YamagishiKohei YoshitakeDaiki KamataniKenji WatanabeHiroaki TsukanoRyuichi HishidaKuniyuki TakahashiSugata TakahashiArata HoriiTakeshi YagiKatsuei ShibukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
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Medicine R Science Q |
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Medicine R Science Q Tatsuya Yamagishi Kohei Yoshitake Daiki Kamatani Kenji Watanabe Hiroaki Tsukano Ryuichi Hishida Kuniyuki Takahashi Sugata Takahashi Arata Horii Takeshi Yagi Katsuei Shibuki Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| description |
Abstract Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by homophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory. |
| format |
article |
| author |
Tatsuya Yamagishi Kohei Yoshitake Daiki Kamatani Kenji Watanabe Hiroaki Tsukano Ryuichi Hishida Kuniyuki Takahashi Sugata Takahashi Arata Horii Takeshi Yagi Katsuei Shibuki |
| author_facet |
Tatsuya Yamagishi Kohei Yoshitake Daiki Kamatani Kenji Watanabe Hiroaki Tsukano Ryuichi Hishida Kuniyuki Takahashi Sugata Takahashi Arata Horii Takeshi Yagi Katsuei Shibuki |
| author_sort |
Tatsuya Yamagishi |
| title |
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| title_short |
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| title_full |
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| title_fullStr |
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| title_full_unstemmed |
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| title_sort |
molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/76dd807a63434fb9810b1cdb6dd57bdf |
| work_keys_str_mv |
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