The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial

We analyzed the effectiveness of two nutritional interventions alone and together, EVOO and the DieTBra, on the inflammatory profile of severely obese individuals. This study was an RCT with 149 individuals aged from 18 to 65 years, with a body mass index ≥ 35 kg/m<sup>2</sup>, randomize...

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Autores principales:	Rafael Longhi, Annelisa Silva e Alves de Carvalho Santos, Anallely López-Yerena, Ana Paula Santos Rodrigues, Cesar de Oliveira, Erika Aparecida Silveira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	severe obesity leukocytes lymphocyte monocytes inflammation nutritional intervention Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/76dda2b7e3c0422189ac7399b0c90348
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spelling	oai:doaj.org-article:76dda2b7e3c0422189ac7399b0c903482021-11-25T18:37:03ZThe Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial10.3390/nu131141392072-6643https://doaj.org/article/76dda2b7e3c0422189ac7399b0c903482021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4139https://doaj.org/toc/2072-6643We analyzed the effectiveness of two nutritional interventions alone and together, EVOO and the DieTBra, on the inflammatory profile of severely obese individuals. This study was an RCT with 149 individuals aged from 18 to 65 years, with a body mass index ≥ 35 kg/m<sup>2</sup>, randomized into three intervention groups: (1) 52 mL/day of EVOO (<i>n</i> = 50); (2) DieTBra (<i>n</i> = 49); and (3) DieTBra plus 52 mL/day of EVOO (DieTBra + EVOO, <i>n</i> = 50). The primary outcomes we measured were the-neutrophil-to-lymphocyte ratio (NLR) and the secondary outcomes we measured were the lymphocyte-to-monocyte ratio (LMR); leukocytes; and C reactive protein (CRP). After 12 weeks of intervention, DieTBra + EVOO significantly reduced the total leucocytes (<i>p</i> = 0.037) and LMR (<i>p</i> = 0.008). No statistically significant differences were found for the NLR in neither the intra-group and inter-group analyses, although a slight reduction was found in the DieTBra group (−0.22 ± 1.87). We observed reductions in the total leukocytes and LMR in the three groups, though without statistical difference between groups. In conclusion, nutritional intervention with DietBra + EVOO promotes a significant reduction in inflammatory biomarkers, namely leukocytes and LMR. CRP was reduced in EVOO and DieTBra groups and NLR reduced in the DieTBra group. This study was registered at ClinicalTrials.gov under NCT02463435.Rafael LonghiAnnelisa Silva e Alves de Carvalho SantosAnallely López-YerenaAna Paula Santos RodriguesCesar de OliveiraErika Aparecida SilveiraMDPI AGarticlesevere obesityleukocyteslymphocytemonocytesinflammationnutritional interventionNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4139, p 4139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	severe obesity leukocytes lymphocyte monocytes inflammation nutritional intervention Nutrition. Foods and food supply TX341-641
spellingShingle	severe obesity leukocytes lymphocyte monocytes inflammation nutritional intervention Nutrition. Foods and food supply TX341-641 Rafael Longhi Annelisa Silva e Alves de Carvalho Santos Anallely López-Yerena Ana Paula Santos Rodrigues Cesar de Oliveira Erika Aparecida Silveira The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
description	We analyzed the effectiveness of two nutritional interventions alone and together, EVOO and the DieTBra, on the inflammatory profile of severely obese individuals. This study was an RCT with 149 individuals aged from 18 to 65 years, with a body mass index ≥ 35 kg/m<sup>2</sup>, randomized into three intervention groups: (1) 52 mL/day of EVOO (<i>n</i> = 50); (2) DieTBra (<i>n</i> = 49); and (3) DieTBra plus 52 mL/day of EVOO (DieTBra + EVOO, <i>n</i> = 50). The primary outcomes we measured were the-neutrophil-to-lymphocyte ratio (NLR) and the secondary outcomes we measured were the lymphocyte-to-monocyte ratio (LMR); leukocytes; and C reactive protein (CRP). After 12 weeks of intervention, DieTBra + EVOO significantly reduced the total leucocytes (<i>p</i> = 0.037) and LMR (<i>p</i> = 0.008). No statistically significant differences were found for the NLR in neither the intra-group and inter-group analyses, although a slight reduction was found in the DieTBra group (−0.22 ± 1.87). We observed reductions in the total leukocytes and LMR in the three groups, though without statistical difference between groups. In conclusion, nutritional intervention with DietBra + EVOO promotes a significant reduction in inflammatory biomarkers, namely leukocytes and LMR. CRP was reduced in EVOO and DieTBra groups and NLR reduced in the DieTBra group. This study was registered at ClinicalTrials.gov under NCT02463435.
format	article
author	Rafael Longhi Annelisa Silva e Alves de Carvalho Santos Anallely López-Yerena Ana Paula Santos Rodrigues Cesar de Oliveira Erika Aparecida Silveira
author_facet	Rafael Longhi Annelisa Silva e Alves de Carvalho Santos Anallely López-Yerena Ana Paula Santos Rodrigues Cesar de Oliveira Erika Aparecida Silveira
author_sort	Rafael Longhi
title	The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
title_short	The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
title_full	The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
title_fullStr	The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
title_full_unstemmed	The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial
title_sort	effectiveness of extra virgin olive oil and the traditional brazilian diet in reducing the inflammatory profile of individuals with severe obesity: a randomized clinical trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/76dda2b7e3c0422189ac7399b0c90348
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The Effectiveness of Extra Virgin Olive Oil and the Traditional Brazilian Diet in Reducing the Inflammatory Profile of Individuals with Severe Obesity: A Randomized Clinical Trial

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