beta-cell transplantation in diabetes mellitus
Patients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and dec...
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Endocrinology Research Centre
2013
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oai:doaj.org-article:76dfb75ea27948bab0c8ccd6c9bf19062021-11-14T09:00:18Zbeta-cell transplantation in diabetes mellitus2072-03512072-037810.14341/2072-0351-812https://doaj.org/article/76dfb75ea27948bab0c8ccd6c9bf19062013-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/812https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Patients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and decrease in risks for late complications, islet transplantation or complete pancreatic grafting in humans remains a challenge due to necessity of lifetime immunosuppression and increasingly sparse donor resources. Current paper presents a review of modern endeavours to obtain a limitless source for glucose-sensitive insulin secreting cells. We discuss, in particular, complex aspects of beta-cell proliferation and/or neogenesis in vivo, issues with xenogenous pancreatic islets, and latest advances in controlled differentiation of embryonic and induced polypotent stem cells ? the most promising and relevant source of beta-cells.S PellegriniV SordiL PiemontiEndocrinology Research Centrearticlediabetes melliruspancreatic beta-cellsproliferationstem cellsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 3, Pp 11-20 (2013) |
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DOAJ |
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DOAJ |
| language |
EN RU |
| topic |
diabetes mellirus pancreatic beta-cells proliferation stem cells Nutritional diseases. Deficiency diseases RC620-627 |
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diabetes mellirus pancreatic beta-cells proliferation stem cells Nutritional diseases. Deficiency diseases RC620-627 S Pellegrini V Sordi L Piemonti beta-cell transplantation in diabetes mellitus |
| description |
Patients with diabetes mellitus suffer either from destruction of pancreatic beta-cells or progressive deterioration of their function. Thus, transplantation of an intact beta-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and decrease in risks for late complications, islet transplantation or complete pancreatic grafting in humans remains a challenge due to necessity of lifetime immunosuppression and increasingly sparse donor resources. Current paper presents a review of modern endeavours to obtain a limitless source for glucose-sensitive insulin secreting cells. We discuss, in particular, complex aspects of beta-cell proliferation and/or neogenesis in vivo, issues with xenogenous pancreatic islets, and latest advances in controlled differentiation of embryonic and induced polypotent stem cells ? the most promising and relevant source of beta-cells. |
| format |
article |
| author |
S Pellegrini V Sordi L Piemonti |
| author_facet |
S Pellegrini V Sordi L Piemonti |
| author_sort |
S Pellegrini |
| title |
beta-cell transplantation in diabetes mellitus |
| title_short |
beta-cell transplantation in diabetes mellitus |
| title_full |
beta-cell transplantation in diabetes mellitus |
| title_fullStr |
beta-cell transplantation in diabetes mellitus |
| title_full_unstemmed |
beta-cell transplantation in diabetes mellitus |
| title_sort |
beta-cell transplantation in diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2013 |
| url |
https://doaj.org/article/76dfb75ea27948bab0c8ccd6c9bf1906 |
| work_keys_str_mv |
AT spellegrini betacelltransplantationindiabetesmellitus AT vsordi betacelltransplantationindiabetesmellitus AT lpiemonti betacelltransplantationindiabetesmellitus |
| _version_ |
1718429587695730688 |