Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor

Abstract A method to fabricate a bioinspired nanobiosensor using electronic-based artificial taste receptors for glucose diagnosis is presented. Fabricated bioinspired glucose nanobiosensor designated based on an artificial taste bud including an amperometric glucose biosensor and taste bud-inspired...

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Autores principales:	Amin TermehYousefi, Katsumi Tateno, Samira Bagheri, Hirofumi Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76e09b9500434ec8bb87a8b4a6534401
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spelling	oai:doaj.org-article:76e09b9500434ec8bb87a8b4a65344012021-12-02T16:07:46ZDevelopment of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor10.1038/s41598-017-01855-52045-2322https://doaj.org/article/76e09b9500434ec8bb87a8b4a65344012017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01855-5https://doaj.org/toc/2045-2322Abstract A method to fabricate a bioinspired nanobiosensor using electronic-based artificial taste receptors for glucose diagnosis is presented. Fabricated bioinspired glucose nanobiosensor designated based on an artificial taste bud including an amperometric glucose biosensor and taste bud-inspired circuits. In fact, the design of the taste bud-inspired circuits was inspired by the signal-processing mechanism of taste nerves which involves two layers. The first, known as a type II cell, detects the glucose by glucose oxidase and transduces the current signal obtained for the pulse pattern is conducted to the second layer, called type III cell, to induce synchronisation of the neural spiking activity. The oscillation results of fabricated bioinspired glucose nanobiosensor confirmed an increase in the frequency of the output pulse as a function of the glucose concentration. At high glucose concentrations, the bioinspired glucose nanobiosensor showed a pulse train of alternating short and long interpulse intervals. A computational analysis performed to validate the hypothesis, which was successfully reproduced the alternating behaviour of bioinspired glucose our nanobiosensor by increasing the output frequency and alternation of pulse intervals according to the reduction in the resistivity of the biosensor.Amin TermehYousefiKatsumi TatenoSamira BagheriHirofumi TanakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amin TermehYousefi Katsumi Tateno Samira Bagheri Hirofumi Tanaka Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
description	Abstract A method to fabricate a bioinspired nanobiosensor using electronic-based artificial taste receptors for glucose diagnosis is presented. Fabricated bioinspired glucose nanobiosensor designated based on an artificial taste bud including an amperometric glucose biosensor and taste bud-inspired circuits. In fact, the design of the taste bud-inspired circuits was inspired by the signal-processing mechanism of taste nerves which involves two layers. The first, known as a type II cell, detects the glucose by glucose oxidase and transduces the current signal obtained for the pulse pattern is conducted to the second layer, called type III cell, to induce synchronisation of the neural spiking activity. The oscillation results of fabricated bioinspired glucose nanobiosensor confirmed an increase in the frequency of the output pulse as a function of the glucose concentration. At high glucose concentrations, the bioinspired glucose nanobiosensor showed a pulse train of alternating short and long interpulse intervals. A computational analysis performed to validate the hypothesis, which was successfully reproduced the alternating behaviour of bioinspired glucose our nanobiosensor by increasing the output frequency and alternation of pulse intervals according to the reduction in the resistivity of the biosensor.
format	article
author	Amin TermehYousefi Katsumi Tateno Samira Bagheri Hirofumi Tanaka
author_facet	Amin TermehYousefi Katsumi Tateno Samira Bagheri Hirofumi Tanaka
author_sort	Amin TermehYousefi
title	Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
title_short	Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
title_full	Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
title_fullStr	Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
title_full_unstemmed	Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor
title_sort	development of frequency based taste receptors using bioinspired glucose nanobiosensor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/76e09b9500434ec8bb87a8b4a6534401
work_keys_str_mv	AT amintermehyousefi developmentoffrequencybasedtastereceptorsusingbioinspiredglucosenanobiosensor AT katsumitateno developmentoffrequencybasedtastereceptorsusingbioinspiredglucosenanobiosensor AT samirabagheri developmentoffrequencybasedtastereceptorsusingbioinspiredglucosenanobiosensor AT hirofumitanaka developmentoffrequencybasedtastereceptorsusingbioinspiredglucosenanobiosensor
_version_	1718384724102086656

Development of Frequency Based Taste Receptors Using Bioinspired Glucose Nanobiosensor

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