Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study

While the association of periodontitis with Type II diabetes (T2DM) is well-established, the causal relationship remains uncertain. We examined the causal association of periodontitis with glycemic traits (HbA1c, fasting glucose, and fasting insulin) and T2DM using Mendelian randomization (MR) takin...

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Autores principales:	Parth D. Shah, C. M. Schooling, Luisa N. Borrell
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetes glycemic control traits periodontitis epidemiology mendelian randomization causal analysis Genetics QH426-470
Acceso en línea:	https://doaj.org/article/76e1c7c25bc34090a186a4e0085c07d8
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spelling	oai:doaj.org-article:76e1c7c25bc34090a186a4e0085c07d82021-12-01T02:00:08ZImpact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study1664-802110.3389/fgene.2021.767577https://doaj.org/article/76e1c7c25bc34090a186a4e0085c07d82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.767577/fullhttps://doaj.org/toc/1664-8021While the association of periodontitis with Type II diabetes (T2DM) is well-established, the causal relationship remains uncertain. We examined the causal association of periodontitis with glycemic traits (HbA1c, fasting glucose, and fasting insulin) and T2DM using Mendelian randomization (MR) taking advantage of large genome-wide association studies of European and East Asian adults, i.e., the UK Biobank (n ≈ 350,000) (HbA1c), trans-ancestral MAGIC (HbA1c, fasting glucose, and insulin), and DIAMANTE (74,124 cases/824,006 controls), and AGEN for T2DM in Europeans and East Asians, respectively. Periodontitis was instrumented using single-nucleotide polymorphisms (SNPs), strongly and independently predicting liability to periodontitis in each ancestry group. SNP-specific Wald estimates were combined using inverse variance weighting. Sensitivity analyses were performed using the weighted median and MR-Egger with meta-analysis of MR estimates for Europeans and East Asians. Genetically instrumented liability to periodontitis was not associated with glycemic traits or T2DM in either ancestry or when ancestry specific estimates were meta-analyzed. Our findings do not support a causal association of liability to periodontitis with glycemic traits or T2DM. However, further research is required confirming these findings among other racial/ethnic groups, especially groups who carry a heavy burden of both periodontitis and T2DM.Parth D. ShahC. M. SchoolingLuisa N. BorrellFrontiers Media S.A.articlediabetesglycemic control traitsperiodontitisepidemiologymendelian randomizationcausal analysisGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes glycemic control traits periodontitis epidemiology mendelian randomization causal analysis Genetics QH426-470
spellingShingle	diabetes glycemic control traits periodontitis epidemiology mendelian randomization causal analysis Genetics QH426-470 Parth D. Shah C. M. Schooling Luisa N. Borrell Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
description	While the association of periodontitis with Type II diabetes (T2DM) is well-established, the causal relationship remains uncertain. We examined the causal association of periodontitis with glycemic traits (HbA1c, fasting glucose, and fasting insulin) and T2DM using Mendelian randomization (MR) taking advantage of large genome-wide association studies of European and East Asian adults, i.e., the UK Biobank (n ≈ 350,000) (HbA1c), trans-ancestral MAGIC (HbA1c, fasting glucose, and insulin), and DIAMANTE (74,124 cases/824,006 controls), and AGEN for T2DM in Europeans and East Asians, respectively. Periodontitis was instrumented using single-nucleotide polymorphisms (SNPs), strongly and independently predicting liability to periodontitis in each ancestry group. SNP-specific Wald estimates were combined using inverse variance weighting. Sensitivity analyses were performed using the weighted median and MR-Egger with meta-analysis of MR estimates for Europeans and East Asians. Genetically instrumented liability to periodontitis was not associated with glycemic traits or T2DM in either ancestry or when ancestry specific estimates were meta-analyzed. Our findings do not support a causal association of liability to periodontitis with glycemic traits or T2DM. However, further research is required confirming these findings among other racial/ethnic groups, especially groups who carry a heavy burden of both periodontitis and T2DM.
format	article
author	Parth D. Shah C. M. Schooling Luisa N. Borrell
author_facet	Parth D. Shah C. M. Schooling Luisa N. Borrell
author_sort	Parth D. Shah
title	Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
title_short	Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
title_full	Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
title_fullStr	Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
title_full_unstemmed	Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study
title_sort	impact of liability to periodontitis on glycemic control and type ii diabetes risk: a mendelian randomization study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/76e1c7c25bc34090a186a4e0085c07d8
work_keys_str_mv	AT parthdshah impactofliabilitytoperiodontitisonglycemiccontrolandtypeiidiabetesriskamendelianrandomizationstudy AT cmschooling impactofliabilitytoperiodontitisonglycemiccontrolandtypeiidiabetesriskamendelianrandomizationstudy AT luisanborrell impactofliabilitytoperiodontitisonglycemiccontrolandtypeiidiabetesriskamendelianrandomizationstudy
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Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study

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