A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair

A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose...

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Autores principales:	Ying-Yi Lin, Shu-Hsu Lu, Rong Gao, Chia-Hung Kuo, Wen-Hisn Chung, Wei-Chih Lien, Ching-Chou Wu, Yong Diao, Hui-Min David Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/76e2746b854b47b098c7ed1e3d49e834
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spelling	oai:doaj.org-article:76e2746b854b47b098c7ed1e3d49e8342021-11-15T01:19:17ZA Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair1942-099410.1155/2021/5598291https://doaj.org/article/76e2746b854b47b098c7ed1e3d49e8342021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5598291https://doaj.org/toc/1942-0994A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract-loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti-inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate-high antioxidative and anti-inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty-four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract-loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.Ying-Yi LinShu-Hsu LuRong GaoChia-Hung KuoWen-Hisn ChungWei-Chih LienChing-Chou WuYong DiaoHui-Min David WangHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Ying-Yi Lin Shu-Hsu Lu Rong Gao Chia-Hung Kuo Wen-Hisn Chung Wei-Chih Lien Ching-Chou Wu Yong Diao Hui-Min David Wang A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
description	A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract-loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti-inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate-high antioxidative and anti-inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty-four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract-loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.
format	article
author	Ying-Yi Lin Shu-Hsu Lu Rong Gao Chia-Hung Kuo Wen-Hisn Chung Wei-Chih Lien Ching-Chou Wu Yong Diao Hui-Min David Wang
author_facet	Ying-Yi Lin Shu-Hsu Lu Rong Gao Chia-Hung Kuo Wen-Hisn Chung Wei-Chih Lien Ching-Chou Wu Yong Diao Hui-Min David Wang
author_sort	Ying-Yi Lin
title	A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
title_short	A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
title_full	A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
title_fullStr	A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
title_full_unstemmed	A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair
title_sort	novel biocompatible herbal extract-loaded hydrogel for acne treatment and repair
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/76e2746b854b47b098c7ed1e3d49e834
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A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair

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