Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function
Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.
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Nature Portfolio
2017
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oai:doaj.org-article:76e5768290f04b6780cef2511b5d398b2021-12-02T17:06:07ZStress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function10.1038/s41467-017-01783-y2041-1723https://doaj.org/article/76e5768290f04b6780cef2511b5d398b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01783-yhttps://doaj.org/toc/2041-1723Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.Georgia BalsevichAlexander S. HäuslCarola W. MeyerStoyo KaramihalevXixi FengMax L. PöhlmannCarine DournesAndres Uribe-MarinoSara SantarelliChristiana LabermaierKathrin HafnerTianqi MaoMichaela BreitsamerMarily TheodoropoulouChristian NamendorfManfred UhrMarcelo Paez-PeredaGerhard WinterFelix HauschAlon ChenMatthias H. TschöpTheo ReinNils C. GassenMathias V. SchmidtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Georgia Balsevich Alexander S. Häusl Carola W. Meyer Stoyo Karamihalev Xixi Feng Max L. Pöhlmann Carine Dournes Andres Uribe-Marino Sara Santarelli Christiana Labermaier Kathrin Hafner Tianqi Mao Michaela Breitsamer Marily Theodoropoulou Christian Namendorf Manfred Uhr Marcelo Paez-Pereda Gerhard Winter Felix Hausch Alon Chen Matthias H. Tschöp Theo Rein Nils C. Gassen Mathias V. Schmidt Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| description |
Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake. |
| format |
article |
| author |
Georgia Balsevich Alexander S. Häusl Carola W. Meyer Stoyo Karamihalev Xixi Feng Max L. Pöhlmann Carine Dournes Andres Uribe-Marino Sara Santarelli Christiana Labermaier Kathrin Hafner Tianqi Mao Michaela Breitsamer Marily Theodoropoulou Christian Namendorf Manfred Uhr Marcelo Paez-Pereda Gerhard Winter Felix Hausch Alon Chen Matthias H. Tschöp Theo Rein Nils C. Gassen Mathias V. Schmidt |
| author_facet |
Georgia Balsevich Alexander S. Häusl Carola W. Meyer Stoyo Karamihalev Xixi Feng Max L. Pöhlmann Carine Dournes Andres Uribe-Marino Sara Santarelli Christiana Labermaier Kathrin Hafner Tianqi Mao Michaela Breitsamer Marily Theodoropoulou Christian Namendorf Manfred Uhr Marcelo Paez-Pereda Gerhard Winter Felix Hausch Alon Chen Matthias H. Tschöp Theo Rein Nils C. Gassen Mathias V. Schmidt |
| author_sort |
Georgia Balsevich |
| title |
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| title_short |
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| title_full |
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| title_fullStr |
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| title_full_unstemmed |
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function |
| title_sort |
stress-responsive fkbp51 regulates akt2-as160 signaling and metabolic function |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/76e5768290f04b6780cef2511b5d398b |
| work_keys_str_mv |
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