Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

Abstract To date, only a few studies have analyzed the clinical characteristics and genetic features of human granulocytic anaplasmosis (HGA) in South Korea. Thus, in this study, we investigated the clinical characteristics of HGA and methods used for clinical diagnosis. The clinical characteristics...

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Autores principales:	Da Young Kim, Jun-Won Seo, Na Ra Yun, Choon-Mee Kim, Dong-Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76e6303805594c348be1e0f3b5a86ffd
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spelling	oai:doaj.org-article:76e6303805594c348be1e0f3b5a86ffd2021-12-02T14:47:31ZHuman granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea10.1038/s41598-021-90327-y2045-2322https://doaj.org/article/76e6303805594c348be1e0f3b5a86ffd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90327-yhttps://doaj.org/toc/2045-2322Abstract To date, only a few studies have analyzed the clinical characteristics and genetic features of human granulocytic anaplasmosis (HGA) in South Korea. Thus, in this study, we investigated the clinical characteristics of HGA and methods used for clinical diagnosis. The clinical characteristics of patients with HGA were studied retrospectively. We reviewed the medical charts of 21 confirmed patients with HGA admitted to the Chosun University Hospital, located in Gwangju, South Korea. Twenty-one HGA patients visited the hospital 2–30 days (median 7 days) after the onset of symptoms. Fourteen patients (66.7%) had fever, which was alleviated 2 h (range 0–12.75 h) after starting treatment with doxycycline. Of the 18 patients who underwent peripheral blood (PB) smear test, only one (5.6%) had morulae. Additionally, only 4/17 patients (23.5%) had morulae in the PB smear reconducted after the confirmation of anaplasmosis. All 21 patients recovered without significant complications. As per results of the blood tests conducted at the time of admission, 7/21 (33.3%) and 5/21 (23.8%) patients showed at least 1:16 and 1:80 of IgM and IgG titers, respectively. Most HGA patients in Korea recovered without significant complications. The indirect immunofluorescence antibody diagnosis or morulae identification for HGA in this study had low sensitivity in the early stage of the disease.Da Young KimJun-Won SeoNa Ra YunChoon-Mee KimDong-Min KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Da Young Kim Jun-Won Seo Na Ra Yun Choon-Mee Kim Dong-Min Kim Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
description	Abstract To date, only a few studies have analyzed the clinical characteristics and genetic features of human granulocytic anaplasmosis (HGA) in South Korea. Thus, in this study, we investigated the clinical characteristics of HGA and methods used for clinical diagnosis. The clinical characteristics of patients with HGA were studied retrospectively. We reviewed the medical charts of 21 confirmed patients with HGA admitted to the Chosun University Hospital, located in Gwangju, South Korea. Twenty-one HGA patients visited the hospital 2–30 days (median 7 days) after the onset of symptoms. Fourteen patients (66.7%) had fever, which was alleviated 2 h (range 0–12.75 h) after starting treatment with doxycycline. Of the 18 patients who underwent peripheral blood (PB) smear test, only one (5.6%) had morulae. Additionally, only 4/17 patients (23.5%) had morulae in the PB smear reconducted after the confirmation of anaplasmosis. All 21 patients recovered without significant complications. As per results of the blood tests conducted at the time of admission, 7/21 (33.3%) and 5/21 (23.8%) patients showed at least 1:16 and 1:80 of IgM and IgG titers, respectively. Most HGA patients in Korea recovered without significant complications. The indirect immunofluorescence antibody diagnosis or morulae identification for HGA in this study had low sensitivity in the early stage of the disease.
format	article
author	Da Young Kim Jun-Won Seo Na Ra Yun Choon-Mee Kim Dong-Min Kim
author_facet	Da Young Kim Jun-Won Seo Na Ra Yun Choon-Mee Kim Dong-Min Kim
author_sort	Da Young Kim
title	Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
title_short	Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
title_full	Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
title_fullStr	Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
title_full_unstemmed	Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea
title_sort	human granulocytic anaplasmosis in a single university hospital in the republic of korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76e6303805594c348be1e0f3b5a86ffd
work_keys_str_mv	AT dayoungkim humangranulocyticanaplasmosisinasingleuniversityhospitalintherepublicofkorea AT junwonseo humangranulocyticanaplasmosisinasingleuniversityhospitalintherepublicofkorea AT narayun humangranulocyticanaplasmosisinasingleuniversityhospitalintherepublicofkorea AT choonmeekim humangranulocyticanaplasmosisinasingleuniversityhospitalintherepublicofkorea AT dongminkim humangranulocyticanaplasmosisinasingleuniversityhospitalintherepublicofkorea
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Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea

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