A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids
Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, the authors report an efficient network-based drug-screening platform developed by integrating mathematical modeling and the pathological features...
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Nature Portfolio
2021
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oai:doaj.org-article:76e852796f214d3b97b10bab8107b2db2021-12-02T15:22:39ZA logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids10.1038/s41467-020-20440-52041-1723https://doaj.org/article/76e852796f214d3b97b10bab8107b2db2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20440-5https://doaj.org/toc/2041-1723Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, the authors report an efficient network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of human cerebral organoids.Jong-Chan ParkSo-Yeong JangDongjoon LeeJeongha LeeUiryong KangHongjun ChangHaeng Jun KimSun-Ho HanJinsoo SeoMurim ChoiDong Young LeeMin Soo ByunDahyun YiKwang-Hyun ChoInhee Mook-JungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jong-Chan Park So-Yeong Jang Dongjoon Lee Jeongha Lee Uiryong Kang Hongjun Chang Haeng Jun Kim Sun-Ho Han Jinsoo Seo Murim Choi Dong Young Lee Min Soo Byun Dahyun Yi Kwang-Hyun Cho Inhee Mook-Jung A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| description |
Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, the authors report an efficient network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of human cerebral organoids. |
| format |
article |
| author |
Jong-Chan Park So-Yeong Jang Dongjoon Lee Jeongha Lee Uiryong Kang Hongjun Chang Haeng Jun Kim Sun-Ho Han Jinsoo Seo Murim Choi Dong Young Lee Min Soo Byun Dahyun Yi Kwang-Hyun Cho Inhee Mook-Jung |
| author_facet |
Jong-Chan Park So-Yeong Jang Dongjoon Lee Jeongha Lee Uiryong Kang Hongjun Chang Haeng Jun Kim Sun-Ho Han Jinsoo Seo Murim Choi Dong Young Lee Min Soo Byun Dahyun Yi Kwang-Hyun Cho Inhee Mook-Jung |
| author_sort |
Jong-Chan Park |
| title |
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| title_short |
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| title_full |
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| title_fullStr |
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| title_full_unstemmed |
A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids |
| title_sort |
logical network-based drug-screening platform for alzheimer’s disease representing pathological features of human brain organoids |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/76e852796f214d3b97b10bab8107b2db |
| work_keys_str_mv |
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