Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

Abstract This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal heal...

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Autores principales:	M. P. M. Adriaanse, A. Mubarak, R. G. Riedl, F. J. W. Ten Kate, J. G. M. C. Damoiseaux, W. A. Buurman, R. H. J. Houwen, A. C. E. Vreugdenhil, Celiac Disease Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/76eb1bdbc1b74652987ccbd632d75edd
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spelling	oai:doaj.org-article:76eb1bdbc1b74652987ccbd632d75edd2021-12-02T15:06:13ZProgress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP10.1038/s41598-017-07242-42045-2322https://doaj.org/article/76eb1bdbc1b74652987ccbd632d75edd2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07242-4https://doaj.org/toc/2045-2322Abstract This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (<10x upper limit of normal), an increased I-FABP level was found. In all these children the diagnosis of CD was confirmed histologically. After gluten elimination for six weeks I-FABP levels had decreased towards levels in the control group. Measurement of plasma I-FABP, in addition to tTG-IgA, EMA-IgA and HLAtyping, enables non-invasive diagnosing of CD in a substantial number of children, and might therefore be of value in the diagnostic approach of CD.M. P. M. AdriaanseA. MubarakR. G. RiedlF. J. W. Ten KateJ. G. M. C. DamoiseauxW. A. BuurmanR. H. J. HouwenA. C. E. VreugdenhilCeliac Disease Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. P. M. Adriaanse A. Mubarak R. G. Riedl F. J. W. Ten Kate J. G. M. C. Damoiseaux W. A. Buurman R. H. J. Houwen A. C. E. Vreugdenhil Celiac Disease Study Group Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
description	Abstract This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria. Plasma I-FABP levels and tTG-IgA titres were assessed sequentially during six months of follow-up. Eighty children with normal tTG-IgA titres served as control group. In 61/90 (67.8%) of the children in the study group an increased I-FABP level was found; in all these children CD diagnosis was confirmed. Interestingly, in 14/30 (46.7%) children with slightly elevated tTG-IgA titres (<10x upper limit of normal), an increased I-FABP level was found. In all these children the diagnosis of CD was confirmed histologically. After gluten elimination for six weeks I-FABP levels had decreased towards levels in the control group. Measurement of plasma I-FABP, in addition to tTG-IgA, EMA-IgA and HLAtyping, enables non-invasive diagnosing of CD in a substantial number of children, and might therefore be of value in the diagnostic approach of CD.
format	article
author	M. P. M. Adriaanse A. Mubarak R. G. Riedl F. J. W. Ten Kate J. G. M. C. Damoiseaux W. A. Buurman R. H. J. Houwen A. C. E. Vreugdenhil Celiac Disease Study Group
author_facet	M. P. M. Adriaanse A. Mubarak R. G. Riedl F. J. W. Ten Kate J. G. M. C. Damoiseaux W. A. Buurman R. H. J. Houwen A. C. E. Vreugdenhil Celiac Disease Study Group
author_sort	M. P. M. Adriaanse
title	Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
title_short	Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
title_full	Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
title_fullStr	Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
title_full_unstemmed	Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP
title_sort	progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma i-fabp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/76eb1bdbc1b74652987ccbd632d75edd
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Progress towards non-invasive diagnosis and follow-up of celiac disease in children; a prospective multicentre study to the usefulness of plasma I-FABP

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