Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents

Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents

Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies provide the most effective protection of the lungs from viral infections. To induce those essential components of lung immunity against SARS-CoV-2, we tested various immunization protocols involving intranasal del...

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Main Authors: Berislav Bošnjak, Ivan Odak, Joana Barros-Martins, Inga Sandrock, Swantje I. Hammerschmidt, Marc Permanyer, Gwendolyn E. Patzer, Hristo Greorgiev, Rodrigo Gutierrez Jauregui, Alina Tscherne, Jan Hendrik Schwarz, Georgia Kalodimou, George Ssebyatika, Malgorzata Ciurkiewicz, Stefanie Willenzon, Anja Bubke, Jasmin Ristenpart, Christiane Ritter, Tamara Tuchel, Christian Meyer zu Natrup, Dai-Lun Shin, Sabrina Clever, Leonard Limpinsel, Wolfgang Baumgärtner, Thomas Krey, Asisa Volz, Gerd Sutter, Reinhold Förster
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
bronchus-associated lymphoid tissue (BALT)
lungs
modified vaccinia virus Ankara (MVA)
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
spike (S) protein
vaccine
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/76eb9b3576254d289905045704455f62
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https://doaj.org/article/76eb9b3576254d289905045704455f62

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