Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.

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Autores principales:	Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode, Harald Sontheimer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76ee429c0d5743bdbdf32e9dfbd740e1
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spelling	oai:doaj.org-article:76ee429c0d5743bdbdf32e9dfbd740e12021-12-02T15:34:08ZPerineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy10.1038/s41467-018-07113-02041-1723https://doaj.org/article/76ee429c0d5743bdbdf32e9dfbd740e12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07113-0https://doaj.org/toc/2041-1723Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.Bhanu P. TewariLata ChaunsaliSusan L. CampbellDipan C. PatelAdam E. GoodeHarald SontheimerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bhanu P. Tewari Lata Chaunsali Susan L. Campbell Dipan C. Patel Adam E. Goode Harald Sontheimer Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
description	Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
format	article
author	Bhanu P. Tewari Lata Chaunsali Susan L. Campbell Dipan C. Patel Adam E. Goode Harald Sontheimer
author_facet	Bhanu P. Tewari Lata Chaunsali Susan L. Campbell Dipan C. Patel Adam E. Goode Harald Sontheimer
author_sort	Bhanu P. Tewari
title	Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
title_short	Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
title_full	Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
title_fullStr	Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
title_full_unstemmed	Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
title_sort	perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/76ee429c0d5743bdbdf32e9dfbd740e1
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Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

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