Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
Guardado en:
Autores principales: | Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode, Harald Sontheimer |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/76ee429c0d5743bdbdf32e9dfbd740e1 |
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