Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion.

The membrane-anchored proteins of enveloped viruses form labile spikes on the virion surface, primed to undergo large-scale conformational changes culminating in virus-cell membrane fusion and viral entry. The prefusion form of these envelope glycoproteins thus represents an important molecular targ...

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Autores principales: Celestine J Thomas, Sundaresh Shankar, Hedi E Casquilho-Gray, Joanne York, Stephen R Sprang, Jack H Nunberg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/76eedbf6a2724be3b76519ce2b784290
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