Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites

Dietary intervention with plant protein is one of the main methods that is used to lessen the symptoms of malnutrition. Supplementary soy protein to undernourished weaning rats for 6 weeks significantly increased their body weight gain. After the intervention, the level of total short-chain fatty ac...

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Autores principales:	Zuchen Wei, Nong Zhou, Liang Zou, Zhenxing Shi, Baoqing Dun, Guixing Ren, Yang Yao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	untargeted metabolomics undernourished microbiota 16S rRNA soy protein Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/76f1ecf96ffc4e1bb7eec0e5e9d742b3
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spelling	oai:doaj.org-article:76f1ecf96ffc4e1bb7eec0e5e9d742b32021-12-02T11:55:37ZSoy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites2296-861X10.3389/fnut.2021.774203https://doaj.org/article/76f1ecf96ffc4e1bb7eec0e5e9d742b32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.774203/fullhttps://doaj.org/toc/2296-861XDietary intervention with plant protein is one of the main methods that is used to lessen the symptoms of malnutrition. Supplementary soy protein to undernourished weaning rats for 6 weeks significantly increased their body weight gain. After the intervention, the level of total short-chain fatty acids (SCFAs) was restored to 1,512.7 μg/g, while the level was only 637.1 μg/g in the 7% protein group. The amino acids (valine, isoleucine, phenylalanine, and tryptophan) increased in the colon, and vitamin B6 metabolism was significantly influenced in undernourished rats. The tryptophan and glycine-serine-threonine pathways were elevated, leading to an increase in the level of tryptophan and 5-hydroxytryptophan (5-HTP) in the serum. In addition, the relative abundance of Lachnospiraceae_NK4A136_group and Lactobacillus increased, while Enterococcus and Streptococcus decreased compared to undernourished rats. Overall, soy protein improved the growth of rats with malnutrition in early life by regulating gut microbiota and metabolites in the colon and serum.Zuchen WeiZuchen WeiNong ZhouLiang ZouZhenxing ShiBaoqing DunGuixing RenYang YaoFrontiers Media S.A.articleuntargeted metabolomicsundernourishedmicrobiota16S rRNAsoy proteinNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	untargeted metabolomics undernourished microbiota 16S rRNA soy protein Nutrition. Foods and food supply TX341-641
spellingShingle	untargeted metabolomics undernourished microbiota 16S rRNA soy protein Nutrition. Foods and food supply TX341-641 Zuchen Wei Zuchen Wei Nong Zhou Liang Zou Zhenxing Shi Baoqing Dun Guixing Ren Yang Yao Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
description	Dietary intervention with plant protein is one of the main methods that is used to lessen the symptoms of malnutrition. Supplementary soy protein to undernourished weaning rats for 6 weeks significantly increased their body weight gain. After the intervention, the level of total short-chain fatty acids (SCFAs) was restored to 1,512.7 μg/g, while the level was only 637.1 μg/g in the 7% protein group. The amino acids (valine, isoleucine, phenylalanine, and tryptophan) increased in the colon, and vitamin B6 metabolism was significantly influenced in undernourished rats. The tryptophan and glycine-serine-threonine pathways were elevated, leading to an increase in the level of tryptophan and 5-hydroxytryptophan (5-HTP) in the serum. In addition, the relative abundance of Lachnospiraceae_NK4A136_group and Lactobacillus increased, while Enterococcus and Streptococcus decreased compared to undernourished rats. Overall, soy protein improved the growth of rats with malnutrition in early life by regulating gut microbiota and metabolites in the colon and serum.
format	article
author	Zuchen Wei Zuchen Wei Nong Zhou Liang Zou Zhenxing Shi Baoqing Dun Guixing Ren Yang Yao
author_facet	Zuchen Wei Zuchen Wei Nong Zhou Liang Zou Zhenxing Shi Baoqing Dun Guixing Ren Yang Yao
author_sort	Zuchen Wei
title	Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
title_short	Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
title_full	Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
title_fullStr	Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
title_full_unstemmed	Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites
title_sort	soy protein alleviates malnutrition in weaning rats by regulating gut microbiota composition and serum metabolites
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/76f1ecf96ffc4e1bb7eec0e5e9d742b3
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Soy Protein Alleviates Malnutrition in Weaning Rats by Regulating Gut Microbiota Composition and Serum Metabolites

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