The Role of IL-17 Cytokines in Psoriasis

Megan Mosca, Julie Hong, Edward Hadeler, Marwa Hakimi, Wilson Liao, Tina Bhutani Psoriasis and Skin Treatment Center, Department of Dermatology, University of California San Francisco, San Francisco, CA, USACorrespondence: Megan MoscaPsoriasis and Skin Treatment Center, Department of Dermatology, Un...

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Autores principales:	Mosca M, Hong J, Hadeler E, Hakimi M, Liao W, Bhutani T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	il-17 plaque psoriasis pathogenesis biologics immune pathway Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/76f34b0ebab54db5a84262b8f0a2c713
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spelling	oai:doaj.org-article:76f34b0ebab54db5a84262b8f0a2c7132021-11-23T18:43:02ZThe Role of IL-17 Cytokines in Psoriasis2253-1556https://doaj.org/article/76f34b0ebab54db5a84262b8f0a2c7132021-11-01T00:00:00Zhttps://www.dovepress.com/the-role-of-il-17-cytokines-in-psoriasis-peer-reviewed-fulltext-article-ITThttps://doaj.org/toc/2253-1556Megan Mosca, Julie Hong, Edward Hadeler, Marwa Hakimi, Wilson Liao, Tina Bhutani Psoriasis and Skin Treatment Center, Department of Dermatology, University of California San Francisco, San Francisco, CA, USACorrespondence: Megan MoscaPsoriasis and Skin Treatment Center, Department of Dermatology, University of California San Francisco, 515 Spruce Street, San Francisco, CA, 94118, USAEmail mmosca@med.unr.eduAbstract: Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward cycle seen within plaque psoriasis. The IL-17 pathway is also hypothesized to modulate the inflammatory responses linking comorbid systemic diseases with psoriasis. Furthermore, the robust clinical response seen with current and emerging therapies targeting IL-17 emphasizes the importance of the IL-17 cytokines in the pathogenesis of psoriasis.Keywords: IL-17, plaque psoriasis, pathogenesis, biologics, immune pathwayMosca MHong JHadeler EHakimi MLiao WBhutani TDove Medical Pressarticleil-17plaque psoriasispathogenesisbiologicsimmune pathwayImmunologic diseases. AllergyRC581-607ENImmunoTargets and Therapy, Vol Volume 10, Pp 409-418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	il-17 plaque psoriasis pathogenesis biologics immune pathway Immunologic diseases. Allergy RC581-607
spellingShingle	il-17 plaque psoriasis pathogenesis biologics immune pathway Immunologic diseases. Allergy RC581-607 Mosca M Hong J Hadeler E Hakimi M Liao W Bhutani T The Role of IL-17 Cytokines in Psoriasis
description	Megan Mosca, Julie Hong, Edward Hadeler, Marwa Hakimi, Wilson Liao, Tina Bhutani Psoriasis and Skin Treatment Center, Department of Dermatology, University of California San Francisco, San Francisco, CA, USACorrespondence: Megan MoscaPsoriasis and Skin Treatment Center, Department of Dermatology, University of California San Francisco, 515 Spruce Street, San Francisco, CA, 94118, USAEmail mmosca@med.unr.eduAbstract: Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation. The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically important role in the pathogenesis of psoriasis. The IL-17 effectors (IL-17A, IL-17C, IL-17E, and IL17F) act on keratinocytes, endothelial cells, and immune cells to stimulate epidermal hyperplasia and the pro-inflammatory feed-forward cycle seen within plaque psoriasis. The IL-17 pathway is also hypothesized to modulate the inflammatory responses linking comorbid systemic diseases with psoriasis. Furthermore, the robust clinical response seen with current and emerging therapies targeting IL-17 emphasizes the importance of the IL-17 cytokines in the pathogenesis of psoriasis.Keywords: IL-17, plaque psoriasis, pathogenesis, biologics, immune pathway
format	article
author	Mosca M Hong J Hadeler E Hakimi M Liao W Bhutani T
author_facet	Mosca M Hong J Hadeler E Hakimi M Liao W Bhutani T
author_sort	Mosca M
title	The Role of IL-17 Cytokines in Psoriasis
title_short	The Role of IL-17 Cytokines in Psoriasis
title_full	The Role of IL-17 Cytokines in Psoriasis
title_fullStr	The Role of IL-17 Cytokines in Psoriasis
title_full_unstemmed	The Role of IL-17 Cytokines in Psoriasis
title_sort	role of il-17 cytokines in psoriasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/76f34b0ebab54db5a84262b8f0a2c713
work_keys_str_mv	AT moscam theroleofil17cytokinesinpsoriasis AT hongj theroleofil17cytokinesinpsoriasis AT hadelere theroleofil17cytokinesinpsoriasis AT hakimim theroleofil17cytokinesinpsoriasis AT liaow theroleofil17cytokinesinpsoriasis AT bhutanit theroleofil17cytokinesinpsoriasis AT moscam roleofil17cytokinesinpsoriasis AT hongj roleofil17cytokinesinpsoriasis AT hadelere roleofil17cytokinesinpsoriasis AT hakimim roleofil17cytokinesinpsoriasis AT liaow roleofil17cytokinesinpsoriasis AT bhutanit roleofil17cytokinesinpsoriasis
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The Role of IL-17 Cytokines in Psoriasis

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