Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy

Xiao-Xiao Jin,1,2 Yan-Fei Xu,2 Xiang Ying,1 Ye-Qing Qian,2 Peng-Zhen Jin,2 Min-Yue Dong2 1Prenatal Diagnosis Center of Taizhou Hospital, Wenzhou Medical University, Taizhou, 317000, People’s Republic of China; 2Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductiv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jin XX, Xu YF, Ying X, Qian YQ, Jin PZ, Dong MY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	in vitro fertilization-embryo transfer pregnancy noninvasive prenatal testing chromosome aneuploidy amniotic fluid Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/76f3dd7321bc4884906acaf1df2417e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76f3dd7321bc4884906acaf1df2417e1
record_format	dspace
spelling	oai:doaj.org-article:76f3dd7321bc4884906acaf1df2417e12021-11-30T18:50:37ZClinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy1179-1411https://doaj.org/article/76f3dd7321bc4884906acaf1df2417e12021-11-01T00:00:00Zhttps://www.dovepress.com/clinical-application-of-noninvasive-prenatal-testing-for-pregnant-wome-peer-reviewed-fulltext-article-IJWHhttps://doaj.org/toc/1179-1411Xiao-Xiao Jin,1,2 Yan-Fei Xu,2 Xiang Ying,1 Ye-Qing Qian,2 Peng-Zhen Jin,2 Min-Yue Dong2 1Prenatal Diagnosis Center of Taizhou Hospital, Wenzhou Medical University, Taizhou, 317000, People’s Republic of China; 2Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductive Genetics, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of ChinaCorrespondence: Min-Yue DongDepartment of Reproductive Genetics, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of ChinaTel +86 18957100183Fax +86-571-87061878Email drdong_dmy1226@163.comObjective: This paper analyzes the clinical significance of noninvasive prenatal testing (NIPT) for fetal chromosome aneuploidy in the screening of in vitro fertilization–embryo transfer (IVF) pregnancies.Methods: The study subjects consisted of 3163 IVF-pregnant women who underwent NIPT at the Women’s Hospital, School of Medicine, Zhejiang University and Taizhou Hospital, Zhejiang Province from February 2015 to June 2019. Fetal or neonatal karyotype analysis was carried out in high-risk patients, with subsequent follow-up on pregnancy outcomes.Results: NIPT results of 3163 pregnant women suggested 20 cases of high-risk fetal chromosome aneuploidy, of which 2185 cases were a single pregnancy. Of the 13 cases of high-risk chromosome aneuploidy in single pregnancies, seven were true positive, and six were false positive according to fetal or newborn chromosomal karyotype diagnosis. Twin pregnancies accounted for 978 cases in which NIPT indicated seven cases of high-risk chromosome aneuploidy; six of these cases were true positive, and one case was false positive according to fetal or newborn chromosomal karyotype diagnosis. The specificity, positive predictive value, and false-positive rate of trisomy 21 syndrome in IVF single embryo NIPT were 99.86%, 62.5%, and 0.14%, respectively. The specificity, positive predictive value, and false-positive rate of trisomy 18 syndrome were 99.95%, 66.67%, and 0.05%, respectively. The specificity of trisomy 13 syndrome was 99.91%, and the false-positive rate was 0.09%. The specificity of trisomy 21 syndrome in IVF twin NIPT was 99.89%, the positive predictive value was 83.33%, and the false-positive rate was 0.11%. The specificity and positive predictive value of fetal trisomy 18 syndrome were 100.00%, and the false-positive rate of it were 0.00%. Sensitivity and false-negative rates were 100% in all cases.Conclusion: NIPT is an ideal prenatal test for IVF-pregnant women due to its high sensitivity and specificity in screening for fetal aneuploidy.Keywords: in vitro fertilization–embryo transfer, pregnancy, noninvasive prenatal testing, chromosome, aneuploidy, amniotic fluidJin XXXu YFYing XQian YQJin PZDong MYDove Medical Pressarticlein vitro fertilization-embryo transferpregnancynoninvasive prenatal testingchromosomeaneuploidyamniotic fluidGynecology and obstetricsRG1-991ENInternational Journal of Women's Health, Vol Volume 13, Pp 1167-1174 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	in vitro fertilization-embryo transfer pregnancy noninvasive prenatal testing chromosome aneuploidy amniotic fluid Gynecology and obstetrics RG1-991
spellingShingle	in vitro fertilization-embryo transfer pregnancy noninvasive prenatal testing chromosome aneuploidy amniotic fluid Gynecology and obstetrics RG1-991 Jin XX Xu YF Ying X Qian YQ Jin PZ Dong MY Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
description	Xiao-Xiao Jin,1,2 Yan-Fei Xu,2 Xiang Ying,1 Ye-Qing Qian,2 Peng-Zhen Jin,2 Min-Yue Dong2 1Prenatal Diagnosis Center of Taizhou Hospital, Wenzhou Medical University, Taizhou, 317000, People’s Republic of China; 2Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductive Genetics, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of ChinaCorrespondence: Min-Yue DongDepartment of Reproductive Genetics, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People’s Republic of ChinaTel +86 18957100183Fax +86-571-87061878Email drdong_dmy1226@163.comObjective: This paper analyzes the clinical significance of noninvasive prenatal testing (NIPT) for fetal chromosome aneuploidy in the screening of in vitro fertilization–embryo transfer (IVF) pregnancies.Methods: The study subjects consisted of 3163 IVF-pregnant women who underwent NIPT at the Women’s Hospital, School of Medicine, Zhejiang University and Taizhou Hospital, Zhejiang Province from February 2015 to June 2019. Fetal or neonatal karyotype analysis was carried out in high-risk patients, with subsequent follow-up on pregnancy outcomes.Results: NIPT results of 3163 pregnant women suggested 20 cases of high-risk fetal chromosome aneuploidy, of which 2185 cases were a single pregnancy. Of the 13 cases of high-risk chromosome aneuploidy in single pregnancies, seven were true positive, and six were false positive according to fetal or newborn chromosomal karyotype diagnosis. Twin pregnancies accounted for 978 cases in which NIPT indicated seven cases of high-risk chromosome aneuploidy; six of these cases were true positive, and one case was false positive according to fetal or newborn chromosomal karyotype diagnosis. The specificity, positive predictive value, and false-positive rate of trisomy 21 syndrome in IVF single embryo NIPT were 99.86%, 62.5%, and 0.14%, respectively. The specificity, positive predictive value, and false-positive rate of trisomy 18 syndrome were 99.95%, 66.67%, and 0.05%, respectively. The specificity of trisomy 13 syndrome was 99.91%, and the false-positive rate was 0.09%. The specificity of trisomy 21 syndrome in IVF twin NIPT was 99.89%, the positive predictive value was 83.33%, and the false-positive rate was 0.11%. The specificity and positive predictive value of fetal trisomy 18 syndrome were 100.00%, and the false-positive rate of it were 0.00%. Sensitivity and false-negative rates were 100% in all cases.Conclusion: NIPT is an ideal prenatal test for IVF-pregnant women due to its high sensitivity and specificity in screening for fetal aneuploidy.Keywords: in vitro fertilization–embryo transfer, pregnancy, noninvasive prenatal testing, chromosome, aneuploidy, amniotic fluid
format	article
author	Jin XX Xu YF Ying X Qian YQ Jin PZ Dong MY
author_facet	Jin XX Xu YF Ying X Qian YQ Jin PZ Dong MY
author_sort	Jin XX
title	Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
title_short	Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
title_full	Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
title_fullStr	Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
title_full_unstemmed	Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy
title_sort	clinical application of noninvasive prenatal testing for pregnant women with assisted reproductive pregnancy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/76f3dd7321bc4884906acaf1df2417e1
work_keys_str_mv	AT jinxx clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy AT xuyf clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy AT yingx clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy AT qianyq clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy AT jinpz clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy AT dongmy clinicalapplicationofnoninvasiveprenataltestingforpregnantwomenwithassistedreproductivepregnancy
_version_	1718406332709601280

Clinical Application of Noninvasive Prenatal Testing for Pregnant Women with Assisted Reproductive Pregnancy

Ejemplares similares