Identification and characterization of Cardiac Glycosides as senolytic compounds

Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of...

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Autores principales:	Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino, Joaquín Arribas, Anxo Vidal, Miguel González-Barcia, Manuel Serrano, María I. Loza, Eduardo Domínguez, Manuel Collado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76f6dda146f1406681b8658e9fa1302e
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spelling	oai:doaj.org-article:76f6dda146f1406681b8658e9fa1302e2021-12-02T15:36:23ZIdentification and characterization of Cardiac Glycosides as senolytic compounds10.1038/s41467-019-12888-x2041-1723https://doaj.org/article/76f6dda146f1406681b8658e9fa1302e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12888-xhttps://doaj.org/toc/2041-1723Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis.Francisco Triana-MartínezPilar Picallos-RabinaSabela Da Silva-ÁlvarezFederico PietrocolaSusana LlanosVerónica RodillaEnrica SopranoPablo PedrosaAlba FerreirósMarta BarradasFernanda Hernández-GonzálezMarta LalindeNeus PratsCristina BernadóPatricia GonzálezMaría GómezMaria P. IkonomopoulouPablo J. Fernández-MarcosTomás García-CaballeroPablo del PinoJoaquín ArribasAnxo VidalMiguel González-BarciaManuel SerranoMaría I. LozaEduardo DomínguezManuel ColladoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado Identification and characterization of Cardiac Glycosides as senolytic compounds
description	Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis.
format	article
author	Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado
author_facet	Francisco Triana-Martínez Pilar Picallos-Rabina Sabela Da Silva-Álvarez Federico Pietrocola Susana Llanos Verónica Rodilla Enrica Soprano Pablo Pedrosa Alba Ferreirós Marta Barradas Fernanda Hernández-González Marta Lalinde Neus Prats Cristina Bernadó Patricia González María Gómez Maria P. Ikonomopoulou Pablo J. Fernández-Marcos Tomás García-Caballero Pablo del Pino Joaquín Arribas Anxo Vidal Miguel González-Barcia Manuel Serrano María I. Loza Eduardo Domínguez Manuel Collado
author_sort	Francisco Triana-Martínez
title	Identification and characterization of Cardiac Glycosides as senolytic compounds
title_short	Identification and characterization of Cardiac Glycosides as senolytic compounds
title_full	Identification and characterization of Cardiac Glycosides as senolytic compounds
title_fullStr	Identification and characterization of Cardiac Glycosides as senolytic compounds
title_full_unstemmed	Identification and characterization of Cardiac Glycosides as senolytic compounds
title_sort	identification and characterization of cardiac glycosides as senolytic compounds
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/76f6dda146f1406681b8658e9fa1302e
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Identification and characterization of Cardiac Glycosides as senolytic compounds

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