The interdependent network of gene regulation and metabolism is robust where it needs to be

Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust aga...

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Autores principales: David F. Klosik, Anne Grimbs, Stefan Bornholdt, Marc-Thorsten Hütt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/76f71895ef464ff285dfb42fd0b7998e
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Sumario:Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes.