The interdependent network of gene regulation and metabolism is robust where it needs to be

Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust aga...

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Autores principales:	David F. Klosik, Anne Grimbs, Stefan Bornholdt, Marc-Thorsten Hütt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76f71895ef464ff285dfb42fd0b7998e
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spelling	oai:doaj.org-article:76f71895ef464ff285dfb42fd0b7998e2021-12-02T14:41:09ZThe interdependent network of gene regulation and metabolism is robust where it needs to be10.1038/s41467-017-00587-42041-1723https://doaj.org/article/76f71895ef464ff285dfb42fd0b7998e2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00587-4https://doaj.org/toc/2041-1723Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes.David F. KlosikAnne GrimbsStefan BornholdtMarc-Thorsten HüttNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt The interdependent network of gene regulation and metabolism is robust where it needs to be
description	Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes.
format	article
author	David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt
author_facet	David F. Klosik Anne Grimbs Stefan Bornholdt Marc-Thorsten Hütt
author_sort	David F. Klosik
title	The interdependent network of gene regulation and metabolism is robust where it needs to be
title_short	The interdependent network of gene regulation and metabolism is robust where it needs to be
title_full	The interdependent network of gene regulation and metabolism is robust where it needs to be
title_fullStr	The interdependent network of gene regulation and metabolism is robust where it needs to be
title_full_unstemmed	The interdependent network of gene regulation and metabolism is robust where it needs to be
title_sort	interdependent network of gene regulation and metabolism is robust where it needs to be
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/76f71895ef464ff285dfb42fd0b7998e
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The interdependent network of gene regulation and metabolism is robust where it needs to be

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