Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

<h4>Purpose</h4>Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein...

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Auteurs principaux: Fariba Némati, Catherine de Montrion, Guillaume Lang, Laurence Kraus-Berthier, Guillaume Carita, Xavier Sastre-Garau, Aurélie Berniard, David Vallerand, Olivier Geneste, Ludmilla de Plater, Alain Pierré, Brian Lockhart, Laurence Desjardins, Sophie Piperno-Neumann, Stéphane Depil, Didier Decaudin
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/76fbfa490b634f1296b2e0f84faf5e90
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