MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells

The antiviral activity of MARCH8 has been associated with the downregulation of envelope glycoproteins from a range of different viruses, resulting in reduced incorporation into nascent virions. Here, we show that MARCH8 restricts IAV at a late stage in virus replication, but this was not associate...

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Autores principales:	Fernando Villalón-Letelier, Andrew G. Brooks, Sarah L. Londrigan, Patrick C. Reading
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/770335439f54400c89bec8bfff2b7b94
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spelling	oai:doaj.org-article:770335439f54400c89bec8bfff2b7b942021-11-03T21:52:35ZMARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells2150-751110.1128/mBio.01484-21https://doaj.org/article/770335439f54400c89bec8bfff2b7b942021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01484-21https://doaj.org/toc/2150-7511 The antiviral activity of MARCH8 has been associated with the downregulation of envelope glycoproteins from a range of different viruses, resulting in reduced incorporation into nascent virions. Here, we show that MARCH8 restricts IAV at a late stage in virus replication, but this was not associated with reduced expression of IAV envelope glycoproteins on the surfaces of infected cells, pointing to a distinct mechanism of antiviral activity.Fernando Villalón-LetelierAndrew G. BrooksSarah L. LondriganPatrick C. ReadingAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Fernando Villalón-Letelier Andrew G. Brooks Sarah L. Londrigan Patrick C. Reading MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
description	The antiviral activity of MARCH8 has been associated with the downregulation of envelope glycoproteins from a range of different viruses, resulting in reduced incorporation into nascent virions. Here, we show that MARCH8 restricts IAV at a late stage in virus replication, but this was not associated with reduced expression of IAV envelope glycoproteins on the surfaces of infected cells, pointing to a distinct mechanism of antiviral activity.
format	article
author	Fernando Villalón-Letelier Andrew G. Brooks Sarah L. Londrigan Patrick C. Reading
author_facet	Fernando Villalón-Letelier Andrew G. Brooks Sarah L. Londrigan Patrick C. Reading
author_sort	Fernando Villalón-Letelier
title	MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
title_short	MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
title_full	MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
title_fullStr	MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
title_full_unstemmed	MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
title_sort	march8 restricts influenza a virus infectivity but does not downregulate viral glycoprotein expression at the surface of infected cells
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/770335439f54400c89bec8bfff2b7b94
work_keys_str_mv	AT fernandovillalonletelier march8restrictsinfluenzaavirusinfectivitybutdoesnotdownregulateviralglycoproteinexpressionatthesurfaceofinfectedcells AT andrewgbrooks march8restrictsinfluenzaavirusinfectivitybutdoesnotdownregulateviralglycoproteinexpressionatthesurfaceofinfectedcells AT sarahllondrigan march8restrictsinfluenzaavirusinfectivitybutdoesnotdownregulateviralglycoproteinexpressionatthesurfaceofinfectedcells AT patrickcreading march8restrictsinfluenzaavirusinfectivitybutdoesnotdownregulateviralglycoproteinexpressionatthesurfaceofinfectedcells
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MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells

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