Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression

Microbiology: Cavities-causing bacteria altered by space-like conditions The gene expression patterns, metabolism and physiology of tooth cavities-causing microbes change in a space-like gravity environment. These findings could help explain why astronauts are at a greater risk for dental diseases w...

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Autores principales:	Silvia S. Orsini, April M. Lewis, Kelly C. Rice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/7708490bf3344d2d8953c67cf613f341
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spelling	oai:doaj.org-article:7708490bf3344d2d8953c67cf613f3412021-12-02T11:51:09ZInvestigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression10.1038/s41526-016-0006-42373-8065https://doaj.org/article/7708490bf3344d2d8953c67cf613f3412017-01-01T00:00:00Zhttps://doi.org/10.1038/s41526-016-0006-4https://doaj.org/toc/2373-8065Microbiology: Cavities-causing bacteria altered by space-like conditions The gene expression patterns, metabolism and physiology of tooth cavities-causing microbes change in a space-like gravity environment. These findings could help explain why astronauts are at a greater risk for dental diseases when in space. Kelly Rice and colleagues from the University of Florida, Gainesville, USA, cultured Streptococcus mutans bacteria under simulated microgravity and normal gravity conditions. The bacteria grown in microgravity were more susceptible to killing with hydrogen peroxide, tended to aggregate in more compact cellular structures, showed changes in their metabolite profile and expressed around 250 genes at levels that were either much higher or lower than normal gravity control cultures. These genes included many involved in carbohydrate metabolism, protein production and stress responses. The observed changes collectively suggest that space flight and microgravity could alter the cavities-causing potential of S. mutans.Silvia S. OrsiniApril M. LewisKelly C. RiceNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Silvia S. Orsini April M. Lewis Kelly C. Rice Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
description	Microbiology: Cavities-causing bacteria altered by space-like conditions The gene expression patterns, metabolism and physiology of tooth cavities-causing microbes change in a space-like gravity environment. These findings could help explain why astronauts are at a greater risk for dental diseases when in space. Kelly Rice and colleagues from the University of Florida, Gainesville, USA, cultured Streptococcus mutans bacteria under simulated microgravity and normal gravity conditions. The bacteria grown in microgravity were more susceptible to killing with hydrogen peroxide, tended to aggregate in more compact cellular structures, showed changes in their metabolite profile and expressed around 250 genes at levels that were either much higher or lower than normal gravity control cultures. These genes included many involved in carbohydrate metabolism, protein production and stress responses. The observed changes collectively suggest that space flight and microgravity could alter the cavities-causing potential of S. mutans.
format	article
author	Silvia S. Orsini April M. Lewis Kelly C. Rice
author_facet	Silvia S. Orsini April M. Lewis Kelly C. Rice
author_sort	Silvia S. Orsini
title	Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
title_short	Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
title_full	Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
title_fullStr	Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
title_full_unstemmed	Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression
title_sort	investigation of simulated microgravity effects on streptococcus mutans physiology and global gene expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7708490bf3344d2d8953c67cf613f341
work_keys_str_mv	AT silviasorsini investigationofsimulatedmicrogravityeffectsonstreptococcusmutansphysiologyandglobalgeneexpression AT aprilmlewis investigationofsimulatedmicrogravityeffectsonstreptococcusmutansphysiologyandglobalgeneexpression AT kellycrice investigationofsimulatedmicrogravityeffectsonstreptococcusmutansphysiologyandglobalgeneexpression
_version_	1718395172137467904

Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression

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