Complex I is bypassed during high intensity exercise

During high-intensity exercise, muscles convert glucose to lactate, in a process that is energetically less efficient than respiration. Here the authors develop a computational model based on muscle proteomic data showing that bypassing mitochondrial complex I increases ATP production rates, and val...

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Autores principales:	Avlant Nilsson, Elias Björnson, Mikael Flockhart, Filip J. Larsen, Jens Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7708f790e64b4976bab3e3919e239909
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id	oai:doaj.org-article:7708f790e64b4976bab3e3919e239909
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spelling	oai:doaj.org-article:7708f790e64b4976bab3e3919e2399092021-12-02T16:57:25ZComplex I is bypassed during high intensity exercise10.1038/s41467-019-12934-82041-1723https://doaj.org/article/7708f790e64b4976bab3e3919e2399092019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12934-8https://doaj.org/toc/2041-1723During high-intensity exercise, muscles convert glucose to lactate, in a process that is energetically less efficient than respiration. Here the authors develop a computational model based on muscle proteomic data showing that bypassing mitochondrial complex I increases ATP production rates, and validate these model predictions in an exercise test on 5 subjects.Avlant NilssonElias BjörnsonMikael FlockhartFilip J. LarsenJens NielsenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Avlant Nilsson Elias Björnson Mikael Flockhart Filip J. Larsen Jens Nielsen Complex I is bypassed during high intensity exercise
description	During high-intensity exercise, muscles convert glucose to lactate, in a process that is energetically less efficient than respiration. Here the authors develop a computational model based on muscle proteomic data showing that bypassing mitochondrial complex I increases ATP production rates, and validate these model predictions in an exercise test on 5 subjects.
format	article
author	Avlant Nilsson Elias Björnson Mikael Flockhart Filip J. Larsen Jens Nielsen
author_facet	Avlant Nilsson Elias Björnson Mikael Flockhart Filip J. Larsen Jens Nielsen
author_sort	Avlant Nilsson
title	Complex I is bypassed during high intensity exercise
title_short	Complex I is bypassed during high intensity exercise
title_full	Complex I is bypassed during high intensity exercise
title_fullStr	Complex I is bypassed during high intensity exercise
title_full_unstemmed	Complex I is bypassed during high intensity exercise
title_sort	complex i is bypassed during high intensity exercise
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7708f790e64b4976bab3e3919e239909
work_keys_str_mv	AT avlantnilsson complexiisbypassedduringhighintensityexercise AT eliasbjornson complexiisbypassedduringhighintensityexercise AT mikaelflockhart complexiisbypassedduringhighintensityexercise AT filipjlarsen complexiisbypassedduringhighintensityexercise AT jensnielsen complexiisbypassedduringhighintensityexercise
_version_	1718382574064107520

Complex I is bypassed during high intensity exercise

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