Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3). Here the authors provide evidence that the two mammalian E1 enzymes, Uba1 and Uba6, exert biologically distinct functions.

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Autores principales:	Xianpeng Liu, Bo Zhao, Limin Sun, Karan Bhuripanyo, Yiyang Wang, Yingtao Bi, Ramana V. Davuluri, Duc M. Duong, Dhaval Nanavati, Jun Yin, Hiroaki Kiyokawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/770ad999b01440b0979cab03270cc849
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spelling	oai:doaj.org-article:770ad999b01440b0979cab03270cc8492021-12-02T14:40:36ZOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes10.1038/ncomms142862041-1723https://doaj.org/article/770ad999b01440b0979cab03270cc8492017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14286https://doaj.org/toc/2041-1723The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3). Here the authors provide evidence that the two mammalian E1 enzymes, Uba1 and Uba6, exert biologically distinct functions.Xianpeng LiuBo ZhaoLimin SunKaran BhuripanyoYiyang WangYingtao BiRamana V. DavuluriDuc M. DuongDhaval NanavatiJun YinHiroaki KiyokawaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianpeng Liu Bo Zhao Limin Sun Karan Bhuripanyo Yiyang Wang Yingtao Bi Ramana V. Davuluri Duc M. Duong Dhaval Nanavati Jun Yin Hiroaki Kiyokawa Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
description	The transfer of ubiquitin (UB) to cellular targets is mediated sequentially by three groups of enzymes, UB activating enzyme (E1), UB conjugating enzyme (E2) and UB ligase (E3). Here the authors provide evidence that the two mammalian E1 enzymes, Uba1 and Uba6, exert biologically distinct functions.
format	article
author	Xianpeng Liu Bo Zhao Limin Sun Karan Bhuripanyo Yiyang Wang Yingtao Bi Ramana V. Davuluri Duc M. Duong Dhaval Nanavati Jun Yin Hiroaki Kiyokawa
author_facet	Xianpeng Liu Bo Zhao Limin Sun Karan Bhuripanyo Yiyang Wang Yingtao Bi Ramana V. Davuluri Duc M. Duong Dhaval Nanavati Jun Yin Hiroaki Kiyokawa
author_sort	Xianpeng Liu
title	Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
title_short	Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
title_full	Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
title_fullStr	Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
title_full_unstemmed	Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
title_sort	orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/770ad999b01440b0979cab03270cc849
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Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

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