Retinal vascular tortuosity in obstructive sleep apnea

Amir Mohsenin,1 Vahid Mohsenin,2 Ron A Adelman1 1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Yale Center for Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Purpose: Endothel...

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Autores principales:	Mohsenin A, Mohsenin V, Adelman RA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/770c734888d6456fa983929bd680a835
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spelling	oai:doaj.org-article:770c734888d6456fa983929bd680a8352021-12-02T04:42:22ZRetinal vascular tortuosity in obstructive sleep apnea1177-54671177-5483https://doaj.org/article/770c734888d6456fa983929bd680a8352013-04-01T00:00:00Zhttp://www.dovepress.com/retinal-vascular-tortuosity-in-obstructive-sleep-apnea-a12881https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Amir Mohsenin,1 Vahid Mohsenin,2 Ron A Adelman1 1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Yale Center for Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Purpose: Endothelial dysfunction and vascular disease are common in obstructive sleep apnea (OSA). We sought to examine the retinal vascular manifestations of OSA. Methods: Nine consecutive patients with OSA underwent ophthalmic examination regardless of any ocular complaints. Seven patients without OSA matched for demographics were used as controls. Fundus photographs from both eyes were used to quantitate retinal vascular tortuosity of the temporal arterial and venous arcades using ImageJ digital analysis software. The tortuosity of each vessel from the optic disc rim to the crossing point of a 5 disc diameter (5DD) circle and 10 disc diameter (10DD) circle centered on the optic disc were quantitated. Results: The mean age of patients with OSA in the study was 52 years ± SD of 10 years and 67 years ± SD of 10 years in the control group. The apnea-hypopnea index in patients with OSA ranged from 12 to 102 events/hr of sleep. The nadir oxyhemoglobin saturation during sleep in patients with OSA ranged from 60% to 87%. There was no significant difference in the frequency of diabetes or hypertension between the groups. Total tortuosity was increased at the 5DD (P = 0.011) and 10DD (P = 0.004) marks. Arterial tortuosity was significantly increased at the 10DD mark (P = 0.016). Venular tortuosity was increased at both the 5DD (P = 0.001) and 10DD (P = 0.028) marks. Conclusion: Patients with OSA have increased retinal vascular tortuosity as compared to matched controls. Increased tortuosity of the retinal vasculature may be a novel association with OSA. A larger prospective study will be necessary to further explore this relationship and its clinical significance. Keywords: retinal vessel tortuosity, sleep apnea, retinal vasculature, retinal vascular tortuosityMohsenin AMohsenin VAdelman RADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 787-792 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mohsenin A Mohsenin V Adelman RA Retinal vascular tortuosity in obstructive sleep apnea
description	Amir Mohsenin,1 Vahid Mohsenin,2 Ron A Adelman1 1Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Yale Center for Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Purpose: Endothelial dysfunction and vascular disease are common in obstructive sleep apnea (OSA). We sought to examine the retinal vascular manifestations of OSA. Methods: Nine consecutive patients with OSA underwent ophthalmic examination regardless of any ocular complaints. Seven patients without OSA matched for demographics were used as controls. Fundus photographs from both eyes were used to quantitate retinal vascular tortuosity of the temporal arterial and venous arcades using ImageJ digital analysis software. The tortuosity of each vessel from the optic disc rim to the crossing point of a 5 disc diameter (5DD) circle and 10 disc diameter (10DD) circle centered on the optic disc were quantitated. Results: The mean age of patients with OSA in the study was 52 years ± SD of 10 years and 67 years ± SD of 10 years in the control group. The apnea-hypopnea index in patients with OSA ranged from 12 to 102 events/hr of sleep. The nadir oxyhemoglobin saturation during sleep in patients with OSA ranged from 60% to 87%. There was no significant difference in the frequency of diabetes or hypertension between the groups. Total tortuosity was increased at the 5DD (P = 0.011) and 10DD (P = 0.004) marks. Arterial tortuosity was significantly increased at the 10DD mark (P = 0.016). Venular tortuosity was increased at both the 5DD (P = 0.001) and 10DD (P = 0.028) marks. Conclusion: Patients with OSA have increased retinal vascular tortuosity as compared to matched controls. Increased tortuosity of the retinal vasculature may be a novel association with OSA. A larger prospective study will be necessary to further explore this relationship and its clinical significance. Keywords: retinal vessel tortuosity, sleep apnea, retinal vasculature, retinal vascular tortuosity
format	article
author	Mohsenin A Mohsenin V Adelman RA
author_facet	Mohsenin A Mohsenin V Adelman RA
author_sort	Mohsenin A
title	Retinal vascular tortuosity in obstructive sleep apnea
title_short	Retinal vascular tortuosity in obstructive sleep apnea
title_full	Retinal vascular tortuosity in obstructive sleep apnea
title_fullStr	Retinal vascular tortuosity in obstructive sleep apnea
title_full_unstemmed	Retinal vascular tortuosity in obstructive sleep apnea
title_sort	retinal vascular tortuosity in obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/770c734888d6456fa983929bd680a835
work_keys_str_mv	AT mohsenina retinalvasculartortuosityinobstructivesleepapnea AT mohseninv retinalvasculartortuosityinobstructivesleepapnea AT adelmanra retinalvasculartortuosityinobstructivesleepapnea
_version_	1718401088858619904

Retinal vascular tortuosity in obstructive sleep apnea

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