Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder
Alla Avedisova, Vladimir Borodin, Ksenia Zakharova, Artem AldushinDepartment of Borderline Psychiatry, FGU State Scientific Research Center of Social and Forensic Psychiatry “V.P. Serbsky”, Moscow, RussiaAbstract: The presence of suicidal manifestations (thoughts and beha...
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Dove Medical Press
2009
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oai:doaj.org-article:770cdf6531134993afdd04e67a3786702021-12-02T04:42:22ZEffect of milnacipran on suicidality in patients with mild to moderate depressive disorder1176-63281178-2021https://doaj.org/article/770cdf6531134993afdd04e67a3786702009-07-01T00:00:00Zhttp://www.dovepress.com/effect-of-milnacipran-on-suicidality-in-patients-with-mild-to-moderate-a3395https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Alla Avedisova, Vladimir Borodin, Ksenia Zakharova, Artem AldushinDepartment of Borderline Psychiatry, FGU State Scientific Research Center of Social and Forensic Psychiatry “V.P. Serbsky”, Moscow, RussiaAbstract: The presence of suicidal manifestations (thoughts and behavior) was studied in a cohort of 30 patients with mild to moderate depression during a 6-week treatment with the serotonin-norepinephrine reuptake inhibitor, milnacipran. At baseline mild suicidal thoughts were present in 46.7% of patients, the mean Hamilton Depression Rating Score (HDRS17) was 23.9 ± 1.8 and the mean suicidality score on the Beck Scale for Suicidal Ideation (BSS) was 4.9 ± 4.9. Suicidal thoughts decreased progressively throughout the study in parallel with other depressive symptoms. At no time during treatment was there any indication of an increased suicidal risk. Notably, the items retardation and psychic anxiety on the HDRS17 decreased in parallel. This may possibly explain the lack of any “activation syndrome”, which is occasionally observed at the early stages of therapy with some antidepressants and may be linked to a temporary increase in suicidal ideation. To our knowledge this is the first detailed report of suicidality during treatment with milnacipran.Keywords: suicidality, milnacipran, depression Alla AvedisovaVladimir BorodinKsenia Zakharovaet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 415-420 (2009) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Alla Avedisova Vladimir Borodin Ksenia Zakharova et al Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
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Alla Avedisova, Vladimir Borodin, Ksenia Zakharova, Artem AldushinDepartment of Borderline Psychiatry, FGU State Scientific Research Center of Social and Forensic Psychiatry “V.P. Serbsky”, Moscow, RussiaAbstract: The presence of suicidal manifestations (thoughts and behavior) was studied in a cohort of 30 patients with mild to moderate depression during a 6-week treatment with the serotonin-norepinephrine reuptake inhibitor, milnacipran. At baseline mild suicidal thoughts were present in 46.7% of patients, the mean Hamilton Depression Rating Score (HDRS17) was 23.9 ± 1.8 and the mean suicidality score on the Beck Scale for Suicidal Ideation (BSS) was 4.9 ± 4.9. Suicidal thoughts decreased progressively throughout the study in parallel with other depressive symptoms. At no time during treatment was there any indication of an increased suicidal risk. Notably, the items retardation and psychic anxiety on the HDRS17 decreased in parallel. This may possibly explain the lack of any “activation syndrome”, which is occasionally observed at the early stages of therapy with some antidepressants and may be linked to a temporary increase in suicidal ideation. To our knowledge this is the first detailed report of suicidality during treatment with milnacipran.Keywords: suicidality, milnacipran, depression |
| format |
article |
| author |
Alla Avedisova Vladimir Borodin Ksenia Zakharova et al |
| author_facet |
Alla Avedisova Vladimir Borodin Ksenia Zakharova et al |
| author_sort |
Alla Avedisova |
| title |
Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| title_short |
Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| title_full |
Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| title_fullStr |
Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| title_full_unstemmed |
Effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| title_sort |
effect of milnacipran on suicidality in patients with mild to moderate depressive disorder |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/770cdf6531134993afdd04e67a378670 |
| work_keys_str_mv |
AT allaavedisova effectofmilnacipranonsuicidalityinpatientswithmildtomoderatedepressivedisorder AT vladimirborodin effectofmilnacipranonsuicidalityinpatientswithmildtomoderatedepressivedisorder AT kseniazakharova effectofmilnacipranonsuicidalityinpatientswithmildtomoderatedepressivedisorder AT etal effectofmilnacipranonsuicidalityinpatientswithmildtomoderatedepressivedisorder |
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