IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY

Abstract. We have examined parameters of innate and adaptive immunity, as well as HLA profile in COPD patients living under the conditions of environmental zinc deficiency (Zn levels in the soil < 0.1 mg/kg, and dietary contents of zinc, 9.1 mg/d, as compared to normal lower limit of 15 mg/d)...

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Autores principales:	L. M. Karzakova, N. D. Ukhterova, L. V. Borisova, L. N. Ivanov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic obstructive pulmonary disease immunological disorders immunogenetics zinc deficiency Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/770e386fe1b94abc8113cbff7e45e43c
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spelling	oai:doaj.org-article:770e386fe1b94abc8113cbff7e45e43c2021-11-18T08:03:39ZIMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY1563-06252313-741X10.15789/1563-0625-2008-6-513-518https://doaj.org/article/770e386fe1b94abc8113cbff7e45e43c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/255https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have examined parameters of innate and adaptive immunity, as well as HLA profile in COPD patients living under the conditions of environmental zinc deficiency (Zn levels in the soil < 0.1 mg/kg, and dietary contents of zinc, 9.1 mg/d, as compared to normal lower limit of 15 mg/d). It was shown that the patients with COPD exhibited activation of adaptive humoral immunity, along with suppression of T cell-mediated response and decreased phagocytic activity of neutrophils. Carrier state of HLA-DRB111 и -DQB1301 alleles in inhabitants of zinc-deficient areas is a predisposing factor for COPD development. Meanwhile, DRB101, DQА10101, DQВ1*0501 alleles may be suggested as markers of resistance to this disease. (Med. Immunol., vol. 10, N 6, pp 513-518).L. M. KarzakovaN. D. UkhterovaL. V. BorisovaL. N. IvanovSPb RAACIarticlechronic obstructive pulmonary diseaseimmunological disordersimmunogeneticszinc deficiencyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 513-518 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease immunological disorders immunogenetics zinc deficiency Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease immunological disorders immunogenetics zinc deficiency Immunologic diseases. Allergy RC581-607 L. M. Karzakova N. D. Ukhterova L. V. Borisova L. N. Ivanov IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
description	Abstract. We have examined parameters of innate and adaptive immunity, as well as HLA profile in COPD patients living under the conditions of environmental zinc deficiency (Zn levels in the soil < 0.1 mg/kg, and dietary contents of zinc, 9.1 mg/d, as compared to normal lower limit of 15 mg/d). It was shown that the patients with COPD exhibited activation of adaptive humoral immunity, along with suppression of T cell-mediated response and decreased phagocytic activity of neutrophils. Carrier state of HLA-DRB111 и -DQB1301 alleles in inhabitants of zinc-deficient areas is a predisposing factor for COPD development. Meanwhile, DRB101, DQА10101, DQВ1*0501 alleles may be suggested as markers of resistance to this disease. (Med. Immunol., vol. 10, N 6, pp 513-518).
format	article
author	L. M. Karzakova N. D. Ukhterova L. V. Borisova L. N. Ivanov
author_facet	L. M. Karzakova N. D. Ukhterova L. V. Borisova L. N. Ivanov
author_sort	L. M. Karzakova
title	IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
title_short	IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
title_full	IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
title_fullStr	IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
title_full_unstemmed	IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY
title_sort	immunological and immunogenetic markers of chronic obstructive pulmonary disease under the conditions of environmental zinc deficiency
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/770e386fe1b94abc8113cbff7e45e43c
work_keys_str_mv	AT lmkarzakova immunologicalandimmunogeneticmarkersofchronicobstructivepulmonarydiseaseundertheconditionsofenvironmentalzincdeficiency AT ndukhterova immunologicalandimmunogeneticmarkersofchronicobstructivepulmonarydiseaseundertheconditionsofenvironmentalzincdeficiency AT lvborisova immunologicalandimmunogeneticmarkersofchronicobstructivepulmonarydiseaseundertheconditionsofenvironmentalzincdeficiency AT lnivanov immunologicalandimmunogeneticmarkersofchronicobstructivepulmonarydiseaseundertheconditionsofenvironmentalzincdeficiency
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IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE UNDER THE CONDITIONS OF ENVIRONMENTAL ZINC DEFICIENCY

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