Biased genome editing using the local accumulation of DSB repair molecules system

Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.

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Autores principales:	Shota Nakade, Keiji Mochida, Atsushi Kunii, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, Tetsushi Sakuma, Takashi Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7714049adc384aa7a9920f7849997032
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spelling	oai:doaj.org-article:7714049adc384aa7a9920f78499970322021-12-02T14:40:09ZBiased genome editing using the local accumulation of DSB repair molecules system10.1038/s41467-018-05773-62041-1723https://doaj.org/article/7714049adc384aa7a9920f78499970322018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05773-6https://doaj.org/toc/2041-1723Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.Shota NakadeKeiji MochidaAtsushi KuniiKazuki NakamaeTomomi AidaKohichi TanakaNaoaki SakamotoTetsushi SakumaTakashi YamamotoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shota Nakade Keiji Mochida Atsushi Kunii Kazuki Nakamae Tomomi Aida Kohichi Tanaka Naoaki Sakamoto Tetsushi Sakuma Takashi Yamamoto Biased genome editing using the local accumulation of DSB repair molecules system
description	Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.
format	article
author	Shota Nakade Keiji Mochida Atsushi Kunii Kazuki Nakamae Tomomi Aida Kohichi Tanaka Naoaki Sakamoto Tetsushi Sakuma Takashi Yamamoto
author_facet	Shota Nakade Keiji Mochida Atsushi Kunii Kazuki Nakamae Tomomi Aida Kohichi Tanaka Naoaki Sakamoto Tetsushi Sakuma Takashi Yamamoto
author_sort	Shota Nakade
title	Biased genome editing using the local accumulation of DSB repair molecules system
title_short	Biased genome editing using the local accumulation of DSB repair molecules system
title_full	Biased genome editing using the local accumulation of DSB repair molecules system
title_fullStr	Biased genome editing using the local accumulation of DSB repair molecules system
title_full_unstemmed	Biased genome editing using the local accumulation of DSB repair molecules system
title_sort	biased genome editing using the local accumulation of dsb repair molecules system
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7714049adc384aa7a9920f7849997032
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Biased genome editing using the local accumulation of DSB repair molecules system

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