FDG-PET/CT in predicting aggressiveness of rectal cancer

Abstract Background Treatment response varies significantly among rectal cancer patients. Tumor can show complete regression, stationary appearance, or even tumour progression during the treatment. It is also widely known that the rate of local recurrence is variable. Precise risk stratification of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Iman Sherif Ahmed, Saher Mohamed El Gaafary, Remon Zaher Elia, Rasha S. Hussein
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	FDG-PET/CT Aggressiveness assessment Rectal cancer MTV TLG Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/771c2b7e7cc641bb8e1095f145bb5d00
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:771c2b7e7cc641bb8e1095f145bb5d00
record_format	dspace
spelling	oai:doaj.org-article:771c2b7e7cc641bb8e1095f145bb5d002021-11-21T12:26:47ZFDG-PET/CT in predicting aggressiveness of rectal cancer10.1186/s43055-021-00656-12090-4762https://doaj.org/article/771c2b7e7cc641bb8e1095f145bb5d002021-11-01T00:00:00Zhttps://doi.org/10.1186/s43055-021-00656-1https://doaj.org/toc/2090-4762Abstract Background Treatment response varies significantly among rectal cancer patients. Tumor can show complete regression, stationary appearance, or even tumour progression during the treatment. It is also widely known that the rate of local recurrence is variable. Precise risk stratification of tumor aggressiveness is required for better per patient tailored treatment plan and predicting the overall prognosis of rectal cancer patients The aim of this study was to assess different parameters of baseline [18F] fluorodeoxyglucose positron emission tomography/computed tomography [(18F) FDG-PET/CT] as a non-invasive tool in predicting aggressiveness of the rectal cancer. Results Overall, 33 patients were included [19 moderately differentiated adenocarcinoma, 10 poorly differentiated adenocarcinoma and 4 mucinous adenocarcinomas (MAC)]. SUV estimates (SUV max, SUV mean) were greater in the moderately adenocarcinoma group (p = 0.003 and p = 0.019, respectively). MTV and TLG values were similar between the three histopathological groups (p = 0.763 and p = 0.701, respectively). There was no correlation between SUVmax of primary tumor and MTV (r = 0.034; p = 0.849). However, SUVmax and TLG were significantly correlated (r = 0.517; p = 0.002). Strong correlation between tumor size and MTV (r = 0.489; p = 0.003), and TLG (r = 0.506; p = 0.003) were observed. No significant association was found between MTV and TLG and the clinical stage of rectal cancer. Conclusion Baseline 18F-FDG PET/CT parameters cannot be used alone as a non-invasive diagnostic technique in assessing aggressiveness and prognosis in patients with primary rectal cancer, and further clinical studies are needed before considering the prognostic role of FDG-PET/CT in rectal cancer.Iman Sherif AhmedSaher Mohamed El GaafaryRemon Zaher EliaRasha S. HusseinSpringerOpenarticleFDG-PET/CTAggressiveness assessmentRectal cancerMTVTLGMedical physics. Medical radiology. Nuclear medicineR895-920ENThe Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FDG-PET/CT Aggressiveness assessment Rectal cancer MTV TLG Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	FDG-PET/CT Aggressiveness assessment Rectal cancer MTV TLG Medical physics. Medical radiology. Nuclear medicine R895-920 Iman Sherif Ahmed Saher Mohamed El Gaafary Remon Zaher Elia Rasha S. Hussein FDG-PET/CT in predicting aggressiveness of rectal cancer
description	Abstract Background Treatment response varies significantly among rectal cancer patients. Tumor can show complete regression, stationary appearance, or even tumour progression during the treatment. It is also widely known that the rate of local recurrence is variable. Precise risk stratification of tumor aggressiveness is required for better per patient tailored treatment plan and predicting the overall prognosis of rectal cancer patients The aim of this study was to assess different parameters of baseline [18F] fluorodeoxyglucose positron emission tomography/computed tomography [(18F) FDG-PET/CT] as a non-invasive tool in predicting aggressiveness of the rectal cancer. Results Overall, 33 patients were included [19 moderately differentiated adenocarcinoma, 10 poorly differentiated adenocarcinoma and 4 mucinous adenocarcinomas (MAC)]. SUV estimates (SUV max, SUV mean) were greater in the moderately adenocarcinoma group (p = 0.003 and p = 0.019, respectively). MTV and TLG values were similar between the three histopathological groups (p = 0.763 and p = 0.701, respectively). There was no correlation between SUVmax of primary tumor and MTV (r = 0.034; p = 0.849). However, SUVmax and TLG were significantly correlated (r = 0.517; p = 0.002). Strong correlation between tumor size and MTV (r = 0.489; p = 0.003), and TLG (r = 0.506; p = 0.003) were observed. No significant association was found between MTV and TLG and the clinical stage of rectal cancer. Conclusion Baseline 18F-FDG PET/CT parameters cannot be used alone as a non-invasive diagnostic technique in assessing aggressiveness and prognosis in patients with primary rectal cancer, and further clinical studies are needed before considering the prognostic role of FDG-PET/CT in rectal cancer.
format	article
author	Iman Sherif Ahmed Saher Mohamed El Gaafary Remon Zaher Elia Rasha S. Hussein
author_facet	Iman Sherif Ahmed Saher Mohamed El Gaafary Remon Zaher Elia Rasha S. Hussein
author_sort	Iman Sherif Ahmed
title	FDG-PET/CT in predicting aggressiveness of rectal cancer
title_short	FDG-PET/CT in predicting aggressiveness of rectal cancer
title_full	FDG-PET/CT in predicting aggressiveness of rectal cancer
title_fullStr	FDG-PET/CT in predicting aggressiveness of rectal cancer
title_full_unstemmed	FDG-PET/CT in predicting aggressiveness of rectal cancer
title_sort	fdg-pet/ct in predicting aggressiveness of rectal cancer
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/771c2b7e7cc641bb8e1095f145bb5d00
work_keys_str_mv	AT imansherifahmed fdgpetctinpredictingaggressivenessofrectalcancer AT sahermohamedelgaafary fdgpetctinpredictingaggressivenessofrectalcancer AT remonzaherelia fdgpetctinpredictingaggressivenessofrectalcancer AT rashashussein fdgpetctinpredictingaggressivenessofrectalcancer
_version_	1718419014226542592

FDG-PET/CT in predicting aggressiveness of rectal cancer

Ejemplares similares