Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of HS sequences and structure-activity relations...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rebecca L. Miller, Scott E. Guimond, Ralf Schwörer, Olga V. Zubkova, Peter C. Tyler, Yongmei Xu, Jian Liu, Pradeep Chopra, Geert-Jan Boons, Márkó Grabarics, Christian Manz, Johanna Hofmann, Niclas G. Karlsson, Jeremy E. Turnbull, Weston B. Struwe, Kevin Pagel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/771c43443fb14659b5131577553e2f14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:771c43443fb14659b5131577553e2f14
record_format	dspace
spelling	oai:doaj.org-article:771c43443fb14659b5131577553e2f142021-12-02T14:42:11ZShotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides10.1038/s41467-020-15284-y2041-1723https://doaj.org/article/771c43443fb14659b5131577553e2f142020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15284-yhttps://doaj.org/toc/2041-1723Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of HS sequences and structure-activity relationships.Rebecca L. MillerScott E. GuimondRalf SchwörerOlga V. ZubkovaPeter C. TylerYongmei XuJian LiuPradeep ChopraGeert-Jan BoonsMárkó GrabaricsChristian ManzJohanna HofmannNiclas G. KarlssonJeremy E. TurnbullWeston B. StruweKevin PagelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca L. Miller Scott E. Guimond Ralf Schwörer Olga V. Zubkova Peter C. Tyler Yongmei Xu Jian Liu Pradeep Chopra Geert-Jan Boons Márkó Grabarics Christian Manz Johanna Hofmann Niclas G. Karlsson Jeremy E. Turnbull Weston B. Struwe Kevin Pagel Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
description	Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of HS sequences and structure-activity relationships.
format	article
author	Rebecca L. Miller Scott E. Guimond Ralf Schwörer Olga V. Zubkova Peter C. Tyler Yongmei Xu Jian Liu Pradeep Chopra Geert-Jan Boons Márkó Grabarics Christian Manz Johanna Hofmann Niclas G. Karlsson Jeremy E. Turnbull Weston B. Struwe Kevin Pagel
author_facet	Rebecca L. Miller Scott E. Guimond Ralf Schwörer Olga V. Zubkova Peter C. Tyler Yongmei Xu Jian Liu Pradeep Chopra Geert-Jan Boons Márkó Grabarics Christian Manz Johanna Hofmann Niclas G. Karlsson Jeremy E. Turnbull Weston B. Struwe Kevin Pagel
author_sort	Rebecca L. Miller
title	Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
title_short	Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
title_full	Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
title_fullStr	Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
title_full_unstemmed	Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
title_sort	shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/771c43443fb14659b5131577553e2f14
work_keys_str_mv	AT rebeccalmiller shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT scotteguimond shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT ralfschworer shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT olgavzubkova shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT peterctyler shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT yongmeixu shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT jianliu shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT pradeepchopra shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT geertjanboons shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT markograbarics shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT christianmanz shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT johannahofmann shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT niclasgkarlsson shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT jeremyeturnbull shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT westonbstruwe shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides AT kevinpagel shotgunionmobilitymassspectrometrysequencingofheparansulfatesaccharides
_version_	1718389757931683840

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Ejemplares similares