FAMILIAL CHRONIC GRANULOMATOUS DISEASE

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of phagocytes, characterized by repeated bacterial and fungal infections. We present a boy suffering from recurrent infections since infancy who was treated with various antibiotics and anti-tuberculosis medicines withou...

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Autores principales:	Tariq Ghafoor, Farrah Bashir
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	tuberculosis chronic granulomatous disease Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/771d19490f8a4404a6bae68bf96828c0
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id	oai:doaj.org-article:771d19490f8a4404a6bae68bf96828c0
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spelling	oai:doaj.org-article:771d19490f8a4404a6bae68bf96828c02021-11-16T05:28:48ZFAMILIAL CHRONIC GRANULOMATOUS DISEASE0030-96482411-8842https://doaj.org/article/771d19490f8a4404a6bae68bf96828c02019-02-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2525/2080https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of phagocytes, characterized by repeated bacterial and fungal infections. We present a boy suffering from recurrent infections since infancy who was treated with various antibiotics and anti-tuberculosis medicines without any relief. All four of his brothers had recurrent respiratory tract infections and were treated empirically with anti-tuberculosis; all of them expired one after the other without any definitive diagnosis. He was diagnosed at ten years of age with pulmonary aspergillosis and CGD. This case highlights pitfalls of medical management of chronic cases in our society. Because of TB endemic area, it is a common practice among physicians to start anti-tuberculosis medicines without making a definite diagnosis. We recommend thorough investigations including testing for CGD in every patient with recurrent or persistent infections especially if other siblings also have similar manifestations.Tariq GhafoorFarrah BashirArmy Medical College Rawalpindiarticletuberculosischronic granulomatous diseaseMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 1, Pp 217-220 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	tuberculosis chronic granulomatous disease Medicine R Medicine (General) R5-920
spellingShingle	tuberculosis chronic granulomatous disease Medicine R Medicine (General) R5-920 Tariq Ghafoor Farrah Bashir FAMILIAL CHRONIC GRANULOMATOUS DISEASE
description	Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of phagocytes, characterized by repeated bacterial and fungal infections. We present a boy suffering from recurrent infections since infancy who was treated with various antibiotics and anti-tuberculosis medicines without any relief. All four of his brothers had recurrent respiratory tract infections and were treated empirically with anti-tuberculosis; all of them expired one after the other without any definitive diagnosis. He was diagnosed at ten years of age with pulmonary aspergillosis and CGD. This case highlights pitfalls of medical management of chronic cases in our society. Because of TB endemic area, it is a common practice among physicians to start anti-tuberculosis medicines without making a definite diagnosis. We recommend thorough investigations including testing for CGD in every patient with recurrent or persistent infections especially if other siblings also have similar manifestations.
format	article
author	Tariq Ghafoor Farrah Bashir
author_facet	Tariq Ghafoor Farrah Bashir
author_sort	Tariq Ghafoor
title	FAMILIAL CHRONIC GRANULOMATOUS DISEASE
title_short	FAMILIAL CHRONIC GRANULOMATOUS DISEASE
title_full	FAMILIAL CHRONIC GRANULOMATOUS DISEASE
title_fullStr	FAMILIAL CHRONIC GRANULOMATOUS DISEASE
title_full_unstemmed	FAMILIAL CHRONIC GRANULOMATOUS DISEASE
title_sort	familial chronic granulomatous disease
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/771d19490f8a4404a6bae68bf96828c0
work_keys_str_mv	AT tariqghafoor familialchronicgranulomatousdisease AT farrahbashir familialchronicgranulomatousdisease
_version_	1718426673435639808

FAMILIAL CHRONIC GRANULOMATOUS DISEASE

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