Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.
Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence. To help optimize the design of future genome-wide-association s...
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oai:doaj.org-article:77205126551d4158baa0e2d203c668602021-11-18T07:33:38ZSensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.1932-620310.1371/journal.pone.0027745https://doaj.org/article/77205126551d4158baa0e2d203c668602011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132133/?tool=EBIhttps://doaj.org/toc/1932-6203Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence. To help optimize the design of future genome-wide-association studies on human taste perception we have used the well-known TAS2R38-PROP association as a tool to determine the relative power and efficiency of different phenotyping and data-analysis strategies. The results show that the choice of both data collection and data processing schemes can have a very substantial impact on the power to detect genotypic variation that affects chemosensory perception. Based on these results we provide practical guidelines for the design of future GWAS studies on chemosensory phenotypes. Moreover, in addition to the TAS2R38 gene past studies have implicated a number of other genetic loci to affect taste sensitivity to PROP and the related bitter compound PTC. None of these other locations showed genome-wide significant associations in our study. To facilitate further, target-gene driven, studies on PROP taste perception we provide the genome-wide list of p-values for all SNPs genotyped in the current study.Ulrich K GenickZoltán KutalikMirko LeddaMaria C Souza DestitoMilena M SouzaCintia A CirilloNicolas GodinotNathalie MartinEdgard MoryaKoichi SameshimaSven BergmannJohannes le CoutrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27745 (2011) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Ulrich K Genick Zoltán Kutalik Mirko Ledda Maria C Souza Destito Milena M Souza Cintia A Cirillo Nicolas Godinot Nathalie Martin Edgard Morya Koichi Sameshima Sven Bergmann Johannes le Coutre Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| description |
Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence. To help optimize the design of future genome-wide-association studies on human taste perception we have used the well-known TAS2R38-PROP association as a tool to determine the relative power and efficiency of different phenotyping and data-analysis strategies. The results show that the choice of both data collection and data processing schemes can have a very substantial impact on the power to detect genotypic variation that affects chemosensory perception. Based on these results we provide practical guidelines for the design of future GWAS studies on chemosensory phenotypes. Moreover, in addition to the TAS2R38 gene past studies have implicated a number of other genetic loci to affect taste sensitivity to PROP and the related bitter compound PTC. None of these other locations showed genome-wide significant associations in our study. To facilitate further, target-gene driven, studies on PROP taste perception we provide the genome-wide list of p-values for all SNPs genotyped in the current study. |
| format |
article |
| author |
Ulrich K Genick Zoltán Kutalik Mirko Ledda Maria C Souza Destito Milena M Souza Cintia A Cirillo Nicolas Godinot Nathalie Martin Edgard Morya Koichi Sameshima Sven Bergmann Johannes le Coutre |
| author_facet |
Ulrich K Genick Zoltán Kutalik Mirko Ledda Maria C Souza Destito Milena M Souza Cintia A Cirillo Nicolas Godinot Nathalie Martin Edgard Morya Koichi Sameshima Sven Bergmann Johannes le Coutre |
| author_sort |
Ulrich K Genick |
| title |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| title_short |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| title_full |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| title_fullStr |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| title_full_unstemmed |
Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark. |
| title_sort |
sensitivity of genome-wide-association signals to phenotyping strategy: the prop-tas2r38 taste association as a benchmark. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/77205126551d4158baa0e2d203c66860 |
| work_keys_str_mv |
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