High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients

Abstract MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulatory function of fundamental cellular proc...

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Autores principales:	Maria Jenvin Stoen, S. Andersen, M. Rakaee, M. I. Pedersen, L. M. Ingebriktsen, R. M. Bremnes, T. Donnem, A. P. G. Lombardi, T. K. Kilvaer, L. T. Busund, E. Richardsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7720b93f13a84037a392d938fe35a950
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spelling	oai:doaj.org-article:7720b93f13a84037a392d938fe35a9502021-12-02T16:14:55ZHigh expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients10.1038/s41598-021-93208-62045-2322https://doaj.org/article/7720b93f13a84037a392d938fe35a9502021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93208-6https://doaj.org/toc/2045-2322Abstract MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulatory function of fundamental cellular processes. In many malignancies, up-regulation of miR-17-5p is associated with worse outcome. In PCa, miR-17-5p has been reported to increase cell proliferation and the risk of metastasis. In this study, prostatectomy specimens from 535 patients were collected. Tissue microarrays were constructed and in situ hybridization was performed, followed by scoring of miR-17-5p expression on different tumor compartments. High expression of miR-17-5p in tumor epithelium was associated with biochemical failure (BF, p < 0.001) and clinical failure (CF, p = 0.019). In multivariate analyses, high miR-17-5p expression in tumor epithelial cells was an independent negative prognostic factor for BF (HR 1.87, 95% CI 1.32–2.67, p < 0.001). In vitro analyses confirmed association between overexpression of miR-17-5p and proliferation, migration and invasion in prostate cancer cell lines (PC3 and DU145). In conclusion, our study suggests that a high cancer cell expression of miR-17-5p was an independent negative prognostic factor in PCa.Maria Jenvin StoenS. AndersenM. RakaeeM. I. PedersenL. M. IngebriktsenR. M. BremnesT. DonnemA. P. G. LombardiT. K. KilvaerL. T. BusundE. RichardsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Jenvin Stoen S. Andersen M. Rakaee M. I. Pedersen L. M. Ingebriktsen R. M. Bremnes T. Donnem A. P. G. Lombardi T. K. Kilvaer L. T. Busund E. Richardsen High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
description	Abstract MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulatory function of fundamental cellular processes. In many malignancies, up-regulation of miR-17-5p is associated with worse outcome. In PCa, miR-17-5p has been reported to increase cell proliferation and the risk of metastasis. In this study, prostatectomy specimens from 535 patients were collected. Tissue microarrays were constructed and in situ hybridization was performed, followed by scoring of miR-17-5p expression on different tumor compartments. High expression of miR-17-5p in tumor epithelium was associated with biochemical failure (BF, p < 0.001) and clinical failure (CF, p = 0.019). In multivariate analyses, high miR-17-5p expression in tumor epithelial cells was an independent negative prognostic factor for BF (HR 1.87, 95% CI 1.32–2.67, p < 0.001). In vitro analyses confirmed association between overexpression of miR-17-5p and proliferation, migration and invasion in prostate cancer cell lines (PC3 and DU145). In conclusion, our study suggests that a high cancer cell expression of miR-17-5p was an independent negative prognostic factor in PCa.
format	article
author	Maria Jenvin Stoen S. Andersen M. Rakaee M. I. Pedersen L. M. Ingebriktsen R. M. Bremnes T. Donnem A. P. G. Lombardi T. K. Kilvaer L. T. Busund E. Richardsen
author_facet	Maria Jenvin Stoen S. Andersen M. Rakaee M. I. Pedersen L. M. Ingebriktsen R. M. Bremnes T. Donnem A. P. G. Lombardi T. K. Kilvaer L. T. Busund E. Richardsen
author_sort	Maria Jenvin Stoen
title	High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
title_short	High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
title_full	High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
title_fullStr	High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
title_full_unstemmed	High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
title_sort	high expression of mir-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7720b93f13a84037a392d938fe35a950
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High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients

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