An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System

Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this...

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Autor principal:	Serghei Covantev
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	central nervous system neuroimmunology mast cells histamine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7728ae7d06314fe591ff2fafa9cf8db0
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spelling	oai:doaj.org-article:7728ae7d06314fe591ff2fafa9cf8db02021-12-02T15:37:21ZAn Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System10.5281/zenodo.42715532695-5075https://doaj.org/article/7728ae7d06314fe591ff2fafa9cf8db02020-12-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4271553https://doaj.org/toc/2695-5075Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disorders and central nervous system trauma, epilepsy, seizures and tumors. Finally, we evaluate whether they can be used as a targed for pharmaceutical treatment.Serghei CovantevEmergency Department of Hospital San Pedro (Logroño, Spain)articlecentral nervous systemneuroimmunologymast cellshistamineMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 1, Pp 56-64 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	central nervous system neuroimmunology mast cells histamine Medicine (General) R5-920
spellingShingle	central nervous system neuroimmunology mast cells histamine Medicine (General) R5-920 Serghei Covantev An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
description	Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disorders and central nervous system trauma, epilepsy, seizures and tumors. Finally, we evaluate whether they can be used as a targed for pharmaceutical treatment.
format	article
author	Serghei Covantev
author_facet	Serghei Covantev
author_sort	Serghei Covantev
title	An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
title_short	An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
title_full	An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
title_fullStr	An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
title_full_unstemmed	An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System
title_sort	overview of the physiological and pathological role of mast cells in the central nervous system
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/7728ae7d06314fe591ff2fafa9cf8db0
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An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System

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