4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling thro...

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Autores principales:	Niall D. Geoghegan, Cindy Evelyn, Lachlan W. Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S. Marapana, Daryan Kempe, Jennifer K. Thompson, Michael J. Mlodzianoski, Julie Healer, Maté Biro, Alan F. Cowman, Kelly L. Rogers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/772dfa5515904e51b6b3f89dfb973a19
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spelling	oai:doaj.org-article:772dfa5515904e51b6b3f89dfb973a192021-12-02T17:40:00Z4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation10.1038/s41467-021-23626-72041-1723https://doaj.org/article/772dfa5515904e51b6b3f89dfb973a192021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23626-7https://doaj.org/toc/2041-1723Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.Niall D. GeogheganCindy EvelynLachlan W. WhiteheadMichal PasternakPhoebe McDonaldTony TrigliaDanushka S. MarapanaDaryan KempeJennifer K. ThompsonMichael J. MlodzianoskiJulie HealerMaté BiroAlan F. CowmanKelly L. RogersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niall D. Geoghegan Cindy Evelyn Lachlan W. Whitehead Michal Pasternak Phoebe McDonald Tony Triglia Danushka S. Marapana Daryan Kempe Jennifer K. Thompson Michael J. Mlodzianoski Julie Healer Maté Biro Alan F. Cowman Kelly L. Rogers 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
description	Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.
format	article
author	Niall D. Geoghegan Cindy Evelyn Lachlan W. Whitehead Michal Pasternak Phoebe McDonald Tony Triglia Danushka S. Marapana Daryan Kempe Jennifer K. Thompson Michael J. Mlodzianoski Julie Healer Maté Biro Alan F. Cowman Kelly L. Rogers
author_facet	Niall D. Geoghegan Cindy Evelyn Lachlan W. Whitehead Michal Pasternak Phoebe McDonald Tony Triglia Danushka S. Marapana Daryan Kempe Jennifer K. Thompson Michael J. Mlodzianoski Julie Healer Maté Biro Alan F. Cowman Kelly L. Rogers
author_sort	Niall D. Geoghegan
title	4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
title_short	4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
title_full	4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
title_fullStr	4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
title_full_unstemmed	4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
title_sort	4d analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/772dfa5515904e51b6b3f89dfb973a19
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4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

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