LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes

The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their trans...

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Autores principales:	Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/772f71df0ef34744bb2cb5cf399186f5
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spelling	oai:doaj.org-article:772f71df0ef34744bb2cb5cf399186f52021-12-02T14:40:55ZLOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes10.1038/s41467-018-06404-w2041-1723https://doaj.org/article/772f71df0ef34744bb2cb5cf399186f52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06404-whttps://doaj.org/toc/2041-1723The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their translation during Drosophila oogenesis.Li ZhuSuresh K. KandasamySusan E. LiaoRyuya FukunagaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Zhu Suresh K. Kandasamy Susan E. Liao Ryuya Fukunaga LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
description	The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their translation during Drosophila oogenesis.
format	article
author	Li Zhu Suresh K. Kandasamy Susan E. Liao Ryuya Fukunaga
author_facet	Li Zhu Suresh K. Kandasamy Susan E. Liao Ryuya Fukunaga
author_sort	Li Zhu
title	LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
title_short	LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
title_full	LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
title_fullStr	LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
title_full_unstemmed	LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes
title_sort	lotus domain protein marf1 binds ccr4-not deadenylase complex to post-transcriptionally regulate gene expression in oocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/772f71df0ef34744bb2cb5cf399186f5
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LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes

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