Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

Polycystic kidney disease (PKD) is characterized by the formation of large renal cysts, which lead to a decline in renal function. Here the authors show that genetic and chemical inhibition of TMEM16A largely reduces cyst enlargement in an in vivo model of autosomal dominant PKD.

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Autores principales:	Ines Cabrita, Andre Kraus, Julia Katharina Scholz, Kathrin Skoczynski, Rainer Schreiber, Karl Kunzelmann, Björn Buchholz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7732490990024ecd9bc4ad8f822a3861
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spelling	oai:doaj.org-article:7732490990024ecd9bc4ad8f822a38612021-12-02T16:35:13ZCyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo10.1038/s41467-020-18104-52041-1723https://doaj.org/article/7732490990024ecd9bc4ad8f822a38612020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18104-5https://doaj.org/toc/2041-1723Polycystic kidney disease (PKD) is characterized by the formation of large renal cysts, which lead to a decline in renal function. Here the authors show that genetic and chemical inhibition of TMEM16A largely reduces cyst enlargement in an in vivo model of autosomal dominant PKD.Ines CabritaAndre KrausJulia Katharina ScholzKathrin SkoczynskiRainer SchreiberKarl KunzelmannBjörn BuchholzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ines Cabrita Andre Kraus Julia Katharina Scholz Kathrin Skoczynski Rainer Schreiber Karl Kunzelmann Björn Buchholz Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
description	Polycystic kidney disease (PKD) is characterized by the formation of large renal cysts, which lead to a decline in renal function. Here the authors show that genetic and chemical inhibition of TMEM16A largely reduces cyst enlargement in an in vivo model of autosomal dominant PKD.
format	article
author	Ines Cabrita Andre Kraus Julia Katharina Scholz Kathrin Skoczynski Rainer Schreiber Karl Kunzelmann Björn Buchholz
author_facet	Ines Cabrita Andre Kraus Julia Katharina Scholz Kathrin Skoczynski Rainer Schreiber Karl Kunzelmann Björn Buchholz
author_sort	Ines Cabrita
title	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
title_short	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
title_full	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
title_fullStr	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
title_full_unstemmed	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
title_sort	cyst growth in adpkd is prevented by pharmacological and genetic inhibition of tmem16a in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7732490990024ecd9bc4ad8f822a3861
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Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

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