Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

Polycystic kidney disease (PKD) is characterized by the formation of large renal cysts, which lead to a decline in renal function. Here the authors show that genetic and chemical inhibition of TMEM16A largely reduces cyst enlargement in an in vivo model of autosomal dominant PKD.

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Autores principales: Ines Cabrita, Andre Kraus, Julia Katharina Scholz, Kathrin Skoczynski, Rainer Schreiber, Karl Kunzelmann, Björn Buchholz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7732490990024ecd9bc4ad8f822a3861
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