Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices

Steady developments made in nanotechnology-based products have facilitated new perspectives for combating drug-resistant fungi. Silver nanoparticles represent one of the most attractive nanomaterials in biomedicine due to their exclusive optical, electromagnetic, and catalytic properties and antifun...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olga Burduniuc, Andra-Cristina Bostanaru, Mihai Mares, Gabriela Biliuta, Sergiu Coseri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antifungal activity silver nanoparticles pullulan oxidation Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/7735094b8fba456aab57321d5ef9c2e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7735094b8fba456aab57321d5ef9c2e7
record_format	dspace
spelling	oai:doaj.org-article:7735094b8fba456aab57321d5ef9c2e72021-11-25T18:15:54ZSynthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices10.3390/ma142270411996-1944https://doaj.org/article/7735094b8fba456aab57321d5ef9c2e72021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/7041https://doaj.org/toc/1996-1944Steady developments made in nanotechnology-based products have facilitated new perspectives for combating drug-resistant fungi. Silver nanoparticles represent one of the most attractive nanomaterials in biomedicine due to their exclusive optical, electromagnetic, and catalytic properties and antifungal potency compared with other metal nanoparticles. Most studies show that the physicochemical parameters affecting the antifungal potential of AgNPs include the shape, size, surface charge, and concentration and colloidal state. For the present study, pullulan (P) and its oxidized counterpart (PO) have been selected as matrices for the silver nanoparticles’ generation and stabilization (AgNPs). The TEMPO (2,2,6,6-tetramethylpiperidin-1-yl radical)–sodium hypochlorite–sodium bromide system was used for the C6 selective oxidation of pullulan in order to introduce negatively charged carboxylic groups in its structure. The structure and morphology of the synthesized AgNPs were analyzed using FTIR and EDX. The main objective of this study was to elucidate the antifungal activity of AgNPs on the clinical yeasts isolates and compare the performance of AgNPs with the conventional antifungals. In this study, different concentrations of AgNPs were tested to examine antifungal activity on various clinical isolates.Olga BurduniucAndra-Cristina BostanaruMihai MaresGabriela BiliutaSergiu CoseriMDPI AGarticleantifungal activitysilver nanoparticlespullulanoxidationTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 7041, p 7041 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antifungal activity silver nanoparticles pullulan oxidation Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	antifungal activity silver nanoparticles pullulan oxidation Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Olga Burduniuc Andra-Cristina Bostanaru Mihai Mares Gabriela Biliuta Sergiu Coseri Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
description	Steady developments made in nanotechnology-based products have facilitated new perspectives for combating drug-resistant fungi. Silver nanoparticles represent one of the most attractive nanomaterials in biomedicine due to their exclusive optical, electromagnetic, and catalytic properties and antifungal potency compared with other metal nanoparticles. Most studies show that the physicochemical parameters affecting the antifungal potential of AgNPs include the shape, size, surface charge, and concentration and colloidal state. For the present study, pullulan (P) and its oxidized counterpart (PO) have been selected as matrices for the silver nanoparticles’ generation and stabilization (AgNPs). The TEMPO (2,2,6,6-tetramethylpiperidin-1-yl radical)–sodium hypochlorite–sodium bromide system was used for the C6 selective oxidation of pullulan in order to introduce negatively charged carboxylic groups in its structure. The structure and morphology of the synthesized AgNPs were analyzed using FTIR and EDX. The main objective of this study was to elucidate the antifungal activity of AgNPs on the clinical yeasts isolates and compare the performance of AgNPs with the conventional antifungals. In this study, different concentrations of AgNPs were tested to examine antifungal activity on various clinical isolates.
format	article
author	Olga Burduniuc Andra-Cristina Bostanaru Mihai Mares Gabriela Biliuta Sergiu Coseri
author_facet	Olga Burduniuc Andra-Cristina Bostanaru Mihai Mares Gabriela Biliuta Sergiu Coseri
author_sort	Olga Burduniuc
title	Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
title_short	Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
title_full	Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
title_fullStr	Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
title_full_unstemmed	Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices
title_sort	synthesis, characterization, and antifungal activity of silver nanoparticles embedded in pullulan matrices
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7735094b8fba456aab57321d5ef9c2e7
work_keys_str_mv	AT olgaburduniuc synthesischaracterizationandantifungalactivityofsilvernanoparticlesembeddedinpullulanmatrices AT andracristinabostanaru synthesischaracterizationandantifungalactivityofsilvernanoparticlesembeddedinpullulanmatrices AT mihaimares synthesischaracterizationandantifungalactivityofsilvernanoparticlesembeddedinpullulanmatrices AT gabrielabiliuta synthesischaracterizationandantifungalactivityofsilvernanoparticlesembeddedinpullulanmatrices AT sergiucoseri synthesischaracterizationandantifungalactivityofsilvernanoparticlesembeddedinpullulanmatrices
_version_	1718411389077291008

Synthesis, Characterization, and Antifungal Activity of Silver Nanoparticles Embedded in Pullulan Matrices

Ejemplares similares