Depression in Parkinson’s disease: Health risks, etiology, and treatment options
Pasquale G Frisina1,2, Joan C Borod3,4, Nancy S Foldi3,5, Harriet R Tenenbaum61Leir Parkinson’s Disease Program, The Jewish Home and Hospital Lifecare System, New York, NY, USA; 2Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA; 3Departm...
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Dove Medical Press
2008
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oai:doaj.org-article:77369d99c4314499aae68c2abb144fb42021-12-02T00:14:08ZDepression in Parkinson’s disease: Health risks, etiology, and treatment options1176-63281178-2021https://doaj.org/article/77369d99c4314499aae68c2abb144fb42008-03-01T00:00:00Zhttp://www.dovepress.com/depression-in-parkinsonrsquos-disease-health-risks-etiology-and-treatm-a998https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Pasquale G Frisina1,2, Joan C Borod3,4, Nancy S Foldi3,5, Harriet R Tenenbaum61Leir Parkinson’s Disease Program, The Jewish Home and Hospital Lifecare System, New York, NY, USA; 2Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA; 3Department of Psychology, Queens College and The Graduate Center of the City University of New York (CUNY), Flushing, NY, USA; 4Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA; 5Department of Medicine, Winthrop-University Hospital, State University of New York, Stony Brook School of Medicine; 6Department of Psychology, Kingston University, Kingston upon Thames, UKAbstract: Depression is found in about 30%–40% of all patients with Parkinson’s disease (PD), but only a small percentage (about 20%) receive treatment. As a consequence, many PD patients suffer with reduced health-related quality of life. To address quality of life in depressed PD patients, we reviewed the literature on the health correlates of depression in PD (eg, cognitive function), etiology of depression in PD, and treatment options (ie, antidepressants, electroconvulsive therapy, and psychotherapy). The current review is unique in its focus on psychosocial aspects, as well as neuropathological factors, of depression in PD. Overall, we conclude that neurochemical (eg, serotonin) and psychosocial factors (eg, coping style, self-esteem, and social support) contribute to the affective disturbances found in this neuropsychiatric population. Therefore, we recommend that a multidisciplinary (eg, pharmacotherapeutic, psychoeducational, and/or psychotherapeutic) approach to treatment be taken with depressed PD patients.Keywords: depression, Parkinson’s disease, health outcomes, treatment options Pasquale G FrisinaJoan C BorodNancy S FoldiHarriet R TenenbaumDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 81-91 (2008) |
| institution |
DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pasquale G Frisina Joan C Borod Nancy S Foldi Harriet R Tenenbaum Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| description |
Pasquale G Frisina1,2, Joan C Borod3,4, Nancy S Foldi3,5, Harriet R Tenenbaum61Leir Parkinson’s Disease Program, The Jewish Home and Hospital Lifecare System, New York, NY, USA; 2Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA; 3Department of Psychology, Queens College and The Graduate Center of the City University of New York (CUNY), Flushing, NY, USA; 4Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA; 5Department of Medicine, Winthrop-University Hospital, State University of New York, Stony Brook School of Medicine; 6Department of Psychology, Kingston University, Kingston upon Thames, UKAbstract: Depression is found in about 30%–40% of all patients with Parkinson’s disease (PD), but only a small percentage (about 20%) receive treatment. As a consequence, many PD patients suffer with reduced health-related quality of life. To address quality of life in depressed PD patients, we reviewed the literature on the health correlates of depression in PD (eg, cognitive function), etiology of depression in PD, and treatment options (ie, antidepressants, electroconvulsive therapy, and psychotherapy). The current review is unique in its focus on psychosocial aspects, as well as neuropathological factors, of depression in PD. Overall, we conclude that neurochemical (eg, serotonin) and psychosocial factors (eg, coping style, self-esteem, and social support) contribute to the affective disturbances found in this neuropsychiatric population. Therefore, we recommend that a multidisciplinary (eg, pharmacotherapeutic, psychoeducational, and/or psychotherapeutic) approach to treatment be taken with depressed PD patients.Keywords: depression, Parkinson’s disease, health outcomes, treatment options |
| format |
article |
| author |
Pasquale G Frisina Joan C Borod Nancy S Foldi Harriet R Tenenbaum |
| author_facet |
Pasquale G Frisina Joan C Borod Nancy S Foldi Harriet R Tenenbaum |
| author_sort |
Pasquale G Frisina |
| title |
Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| title_short |
Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| title_full |
Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| title_fullStr |
Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| title_full_unstemmed |
Depression in Parkinson’s disease: Health risks, etiology, and treatment options |
| title_sort |
depression in parkinson’s disease: health risks, etiology, and treatment options |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/77369d99c4314499aae68c2abb144fb4 |
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