Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

Abstract Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gen...

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Autores principales:	J. P. Gouin, Q. Q. Zhou, L. Booij, M. Boivin, S. M. Côté, M. Hébert, I. Ouellet-Morin, M. Szyf, R. E. Tremblay, G. Turecki, F. Vitaro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7737325d204842fbb9e5544026c7527f
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spelling	oai:doaj.org-article:7737325d204842fbb9e5544026c7527f2021-12-02T16:08:24ZAssociations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness10.1038/s41598-017-07950-x2045-2322https://doaj.org/article/7737325d204842fbb9e5544026c7527f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07950-xhttps://doaj.org/toc/2045-2322Abstract Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.J. P. GouinQ. Q. ZhouL. BooijM. BoivinS. M. CôtéM. HébertI. Ouellet-MorinM. SzyfR. E. TremblayG. TureckiF. VitaroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. P. Gouin Q. Q. Zhou L. Booij M. Boivin S. M. Côté M. Hébert I. Ouellet-Morin M. Szyf R. E. Tremblay G. Turecki F. Vitaro Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
description	Abstract Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.
format	article
author	J. P. Gouin Q. Q. Zhou L. Booij M. Boivin S. M. Côté M. Hébert I. Ouellet-Morin M. Szyf R. E. Tremblay G. Turecki F. Vitaro
author_facet	J. P. Gouin Q. Q. Zhou L. Booij M. Boivin S. M. Côté M. Hébert I. Ouellet-Morin M. Szyf R. E. Tremblay G. Turecki F. Vitaro
author_sort	J. P. Gouin
title	Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
title_short	Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
title_full	Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
title_fullStr	Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
title_full_unstemmed	Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
title_sort	associations among oxytocin receptor gene (oxtr) dna methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7737325d204842fbb9e5544026c7527f
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Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

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