Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders

Aims. To evaluate the prognostic value of adipokines in patients with myocardial infarction (MI) and various glucose metabolism disorders. Materials and Methods. Consecutive patients aged ?80 years and diagnosed with MI (380 patients, 63.4% males) were examined. The patients were classified into f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kamila Kahramonzhonovna Kholmatova, Irina Vladimirovna Dvoryashina, Irina Adolfovna Fomkina, Tatiana Vyacheslavovna Supryadkina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2014
Materias:	diabetes mellitus leptin adiponectin myocardial infarction prognosis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/77383757516d4b40808676d1f52bd9bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:77383757516d4b40808676d1f52bd9bc
record_format	dspace
spelling	oai:doaj.org-article:77383757516d4b40808676d1f52bd9bc2021-11-14T09:00:19ZPrognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders2072-03512072-037810.14341/DM2014390-95https://doaj.org/article/77383757516d4b40808676d1f52bd9bc2014-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6440https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To evaluate the prognostic value of adipokines in patients with myocardial infarction (MI) and various glucose metabolism disorders. Materials and Methods. Consecutive patients aged ?80 years and diagnosed with MI (380 patients, 63.4% males) were examined. The patients were classified into four groups: I, with normal glucose tolerance; II, with prediabetes; III and IV - with newly detected and previously diagnosed type 2 diabetes mellitus, respectively. Levels of insulin, C-peptide and cortisol during glucose tolerance test and basal levels of apolipoproteins AI, B100, leptin and adiponectin were determined in 113 patients with Q MI. Cardiovascular events were analysed for the next 2 years after MI. Logistic regression analysis was used to identify the risk factors of poor prognosis after MI. Results. Elevated levels of leptin with decreased levels of adiponectin were observed in all MI patients independent of the degree of glucose metabolism disturbance. A linear trend of leptin level increase was observed starting from group I to group IV (Jonckheere?s test: J=2218.0; z=3.411; р=0.001). Multiple regression analysis showed that the basal insulin level was an independent predictor of death during the 2 years after MI (OR=0.639; р=0.033). MI prior to hospitalisation (OR=5.633; р=0.013), basal hypercortisolaemia (OR=5.435; р=0.016), glycaemia (OR=1.213; р=0.023) and heart rate (OR=1.051; р=0.032) on admission were associated with the occurrence of repeated MI. Leptin levels (OR=1.018; р=0.031) and creatine kinase-MB fraction (OR=1.009; р=0.018) were risk factors of the occurrence of the combined end-point of cardiovascular events. Conclusion. An imbalance of adipokines was observed in MI patients regardless of the presence of glucose disorders. The levels of leptin, glycaemia, insulin and basal hypercortisolaemia were significantly associated with the occurrence of cardiovascular events during the late post-infarction period.Kamila Kahramonzhonovna KholmatovaIrina Vladimirovna DvoryashinaIrina Adolfovna FomkinaTatiana Vyacheslavovna SupryadkinaEndocrinology Research Centrearticlediabetes mellitusleptin adiponectinmyocardial infarctionprognosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 17, Iss 3, Pp 90-95 (2014)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus leptin adiponectin myocardial infarction prognosis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus leptin adiponectin myocardial infarction prognosis Nutritional diseases. Deficiency diseases RC620-627 Kamila Kahramonzhonovna Kholmatova Irina Vladimirovna Dvoryashina Irina Adolfovna Fomkina Tatiana Vyacheslavovna Supryadkina Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
description	Aims. To evaluate the prognostic value of adipokines in patients with myocardial infarction (MI) and various glucose metabolism disorders. Materials and Methods. Consecutive patients aged ?80 years and diagnosed with MI (380 patients, 63.4% males) were examined. The patients were classified into four groups: I, with normal glucose tolerance; II, with prediabetes; III and IV - with newly detected and previously diagnosed type 2 diabetes mellitus, respectively. Levels of insulin, C-peptide and cortisol during glucose tolerance test and basal levels of apolipoproteins AI, B100, leptin and adiponectin were determined in 113 patients with Q MI. Cardiovascular events were analysed for the next 2 years after MI. Logistic regression analysis was used to identify the risk factors of poor prognosis after MI. Results. Elevated levels of leptin with decreased levels of adiponectin were observed in all MI patients independent of the degree of glucose metabolism disturbance. A linear trend of leptin level increase was observed starting from group I to group IV (Jonckheere?s test: J=2218.0; z=3.411; р=0.001). Multiple regression analysis showed that the basal insulin level was an independent predictor of death during the 2 years after MI (OR=0.639; р=0.033). MI prior to hospitalisation (OR=5.633; р=0.013), basal hypercortisolaemia (OR=5.435; р=0.016), glycaemia (OR=1.213; р=0.023) and heart rate (OR=1.051; р=0.032) on admission were associated with the occurrence of repeated MI. Leptin levels (OR=1.018; р=0.031) and creatine kinase-MB fraction (OR=1.009; р=0.018) were risk factors of the occurrence of the combined end-point of cardiovascular events. Conclusion. An imbalance of adipokines was observed in MI patients regardless of the presence of glucose disorders. The levels of leptin, glycaemia, insulin and basal hypercortisolaemia were significantly associated with the occurrence of cardiovascular events during the late post-infarction period.
format	article
author	Kamila Kahramonzhonovna Kholmatova Irina Vladimirovna Dvoryashina Irina Adolfovna Fomkina Tatiana Vyacheslavovna Supryadkina
author_facet	Kamila Kahramonzhonovna Kholmatova Irina Vladimirovna Dvoryashina Irina Adolfovna Fomkina Tatiana Vyacheslavovna Supryadkina
author_sort	Kamila Kahramonzhonovna Kholmatova
title	Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
title_short	Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
title_full	Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
title_fullStr	Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
title_full_unstemmed	Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
title_sort	prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders
publisher	Endocrinology Research Centre
publishDate	2014
url	https://doaj.org/article/77383757516d4b40808676d1f52bd9bc
work_keys_str_mv	AT kamilakahramonzhonovnakholmatova prognosticvalueofadipokinesinpatientswithmyocardialinfarctionandglucosemetabolismdisorders AT irinavladimirovnadvoryashina prognosticvalueofadipokinesinpatientswithmyocardialinfarctionandglucosemetabolismdisorders AT irinaadolfovnafomkina prognosticvalueofadipokinesinpatientswithmyocardialinfarctionandglucosemetabolismdisorders AT tatianavyacheslavovnasupryadkina prognosticvalueofadipokinesinpatientswithmyocardialinfarctionandglucosemetabolismdisorders
_version_	1718429539611181056

Prognostic value of adipokines in patients with myocardial infarction and glucose metabolism disorders

Ejemplares similares