Intraoperative ureter identification with a novel fluorescent catheter

Abstract Iatrogenic ureteral injuries (IUI) occur in 0.5–1.3% of cases during abdominal surgery. If not recognized intraoperatively, IUI increase morbidity/mortality. A universally accepted method to prevent IUI is lacking. Near-infrared fluorescent imaging (NIRF), penetrating deeper than normal lig...

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Autores principales:	Manuel Barberio, Mahdi Al-Taher, Eric Felli, Anila Hoskere Ashoka, Jacques Marescaux, Andrey Klymchenko, Michele Diana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7739571845594c129159df56a0427ea5
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spelling	oai:doaj.org-article:7739571845594c129159df56a0427ea52021-12-02T13:34:57ZIntraoperative ureter identification with a novel fluorescent catheter10.1038/s41598-021-84121-z2045-2322https://doaj.org/article/7739571845594c129159df56a0427ea52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84121-zhttps://doaj.org/toc/2045-2322Abstract Iatrogenic ureteral injuries (IUI) occur in 0.5–1.3% of cases during abdominal surgery. If not recognized intraoperatively, IUI increase morbidity/mortality. A universally accepted method to prevent IUI is lacking. Near-infrared fluorescent imaging (NIRF), penetrating deeper than normal light within the tissue, might be useful, therefore ureter visualization combining NIRF with special dyes (i.e. IRDye 800BK) is promising. Aim of this work is to evaluate the detection of ureters using stents coated with a novel biocompatible fluorescent material (NICE: near-infrared coating of equipment), during laparoscopy. female pigs underwent placement of NICE-coated stents (NS). NIRF was performed, and fluorescence intensity (FI) was computed. Successively, 0.15 mg/kg of IRDye 800BK was administered intravenously, and FI was computed at different timepoints. Ureter visualization using NS only was further assessed in a human cadaver. Both methods allowed in vivo ureter visualization, with equal FI. However, NS were constantly visible whereas IRDye 800BK allowed visualization exclusively during the ureteral peristaltic phases. In the human cadaver, NS provided excellent ureter visualization in its natural anatomical position. NS provided continuous ureteral visualization with similar FI as the IRDye 800BK, which exclusively allowed intermittent visualization, dependent on ureteral peristalsis. NS might prove useful to visualize ureters intraoperatively, potentially preventing IUI.Manuel BarberioMahdi Al-TaherEric FelliAnila Hoskere AshokaJacques MarescauxAndrey KlymchenkoMichele DianaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuel Barberio Mahdi Al-Taher Eric Felli Anila Hoskere Ashoka Jacques Marescaux Andrey Klymchenko Michele Diana Intraoperative ureter identification with a novel fluorescent catheter
description	Abstract Iatrogenic ureteral injuries (IUI) occur in 0.5–1.3% of cases during abdominal surgery. If not recognized intraoperatively, IUI increase morbidity/mortality. A universally accepted method to prevent IUI is lacking. Near-infrared fluorescent imaging (NIRF), penetrating deeper than normal light within the tissue, might be useful, therefore ureter visualization combining NIRF with special dyes (i.e. IRDye 800BK) is promising. Aim of this work is to evaluate the detection of ureters using stents coated with a novel biocompatible fluorescent material (NICE: near-infrared coating of equipment), during laparoscopy. female pigs underwent placement of NICE-coated stents (NS). NIRF was performed, and fluorescence intensity (FI) was computed. Successively, 0.15 mg/kg of IRDye 800BK was administered intravenously, and FI was computed at different timepoints. Ureter visualization using NS only was further assessed in a human cadaver. Both methods allowed in vivo ureter visualization, with equal FI. However, NS were constantly visible whereas IRDye 800BK allowed visualization exclusively during the ureteral peristaltic phases. In the human cadaver, NS provided excellent ureter visualization in its natural anatomical position. NS provided continuous ureteral visualization with similar FI as the IRDye 800BK, which exclusively allowed intermittent visualization, dependent on ureteral peristalsis. NS might prove useful to visualize ureters intraoperatively, potentially preventing IUI.
format	article
author	Manuel Barberio Mahdi Al-Taher Eric Felli Anila Hoskere Ashoka Jacques Marescaux Andrey Klymchenko Michele Diana
author_facet	Manuel Barberio Mahdi Al-Taher Eric Felli Anila Hoskere Ashoka Jacques Marescaux Andrey Klymchenko Michele Diana
author_sort	Manuel Barberio
title	Intraoperative ureter identification with a novel fluorescent catheter
title_short	Intraoperative ureter identification with a novel fluorescent catheter
title_full	Intraoperative ureter identification with a novel fluorescent catheter
title_fullStr	Intraoperative ureter identification with a novel fluorescent catheter
title_full_unstemmed	Intraoperative ureter identification with a novel fluorescent catheter
title_sort	intraoperative ureter identification with a novel fluorescent catheter
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7739571845594c129159df56a0427ea5
work_keys_str_mv	AT manuelbarberio intraoperativeureteridentificationwithanovelfluorescentcatheter AT mahdialtaher intraoperativeureteridentificationwithanovelfluorescentcatheter AT ericfelli intraoperativeureteridentificationwithanovelfluorescentcatheter AT anilahoskereashoka intraoperativeureteridentificationwithanovelfluorescentcatheter AT jacquesmarescaux intraoperativeureteridentificationwithanovelfluorescentcatheter AT andreyklymchenko intraoperativeureteridentificationwithanovelfluorescentcatheter AT michelediana intraoperativeureteridentificationwithanovelfluorescentcatheter
_version_	1718392744533032960

Intraoperative ureter identification with a novel fluorescent catheter

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