Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population

Abstract Alterations in the regulatory mechanisms that control the process of myelination in the nervous system, may lead to the impaired myelination in the Multiple sclerosis. The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology...

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Autores principales:	Sheyda Khalilian, Zohreh Hojati, Fariba Dehghanian, Vahid Shaygannejad, Seyedeh Zahra Hosseini Imani, Majid Kheirollahi, Mehdi Khorrami, Omid Mirmosayyeb
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Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/773a4cc80f744fb28ad2807b63ac856a
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spelling	oai:doaj.org-article:773a4cc80f744fb28ad2807b63ac856a2021-12-02T14:20:35ZGene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population10.1038/s41598-021-87131-z2045-2322https://doaj.org/article/773a4cc80f744fb28ad2807b63ac856a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87131-zhttps://doaj.org/toc/2045-2322Abstract Alterations in the regulatory mechanisms that control the process of myelination in the nervous system, may lead to the impaired myelination in the Multiple sclerosis. The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology of MS. This study examined via qPCR the RNA expression of YAP1, TAZ, and CRB3 as the key effectors of the Hippo pathway and also, VDR in the peripheral blood of 35 sporadic, 37 familial MS patients; and also 34 healthy first-degree relatives of the familial MS patients (HFR) and 40 healthy individuals without a family history of the disease (control). The results showed the increased expression of VDR in the sporadic group, as compared to other groups. There was also an increased expression of TAZ in the familial and HFR groups, as compared to the control group. The familial and sporadic patients displayed a significantly lower level of expression of YAP1 in comparison to the HFR group. The increased expression level in the sporadic patients and control group, as compared to the HFR group, was seen in CRB3. We also assessed different clinical parameters and MRI characteristics of the patients. Overall, these findings suggest that Hippo pathway effectors and also VDR gene may play a potential role in the pathophysiology of the sporadic and familial forms of MS. Confirmation of different gene expression patterns in sporadic and familial MS groups may have obvious implications for the personalization of therapies in the disease.Sheyda KhalilianZohreh HojatiFariba DehghanianVahid ShaygannejadSeyedeh Zahra Hosseini ImaniMajid KheirollahiMehdi KhorramiOmid MirmosayyebNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sheyda Khalilian Zohreh Hojati Fariba Dehghanian Vahid Shaygannejad Seyedeh Zahra Hosseini Imani Majid Kheirollahi Mehdi Khorrami Omid Mirmosayyeb Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
description	Abstract Alterations in the regulatory mechanisms that control the process of myelination in the nervous system, may lead to the impaired myelination in the Multiple sclerosis. The Hippo pathway is an important mediator of myelination in the nervous system and might contribute to the pathophysiology of MS. This study examined via qPCR the RNA expression of YAP1, TAZ, and CRB3 as the key effectors of the Hippo pathway and also, VDR in the peripheral blood of 35 sporadic, 37 familial MS patients; and also 34 healthy first-degree relatives of the familial MS patients (HFR) and 40 healthy individuals without a family history of the disease (control). The results showed the increased expression of VDR in the sporadic group, as compared to other groups. There was also an increased expression of TAZ in the familial and HFR groups, as compared to the control group. The familial and sporadic patients displayed a significantly lower level of expression of YAP1 in comparison to the HFR group. The increased expression level in the sporadic patients and control group, as compared to the HFR group, was seen in CRB3. We also assessed different clinical parameters and MRI characteristics of the patients. Overall, these findings suggest that Hippo pathway effectors and also VDR gene may play a potential role in the pathophysiology of the sporadic and familial forms of MS. Confirmation of different gene expression patterns in sporadic and familial MS groups may have obvious implications for the personalization of therapies in the disease.
format	article
author	Sheyda Khalilian Zohreh Hojati Fariba Dehghanian Vahid Shaygannejad Seyedeh Zahra Hosseini Imani Majid Kheirollahi Mehdi Khorrami Omid Mirmosayyeb
author_facet	Sheyda Khalilian Zohreh Hojati Fariba Dehghanian Vahid Shaygannejad Seyedeh Zahra Hosseini Imani Majid Kheirollahi Mehdi Khorrami Omid Mirmosayyeb
author_sort	Sheyda Khalilian
title	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
title_short	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
title_full	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
title_fullStr	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
title_full_unstemmed	Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population
title_sort	gene expression profiles of yap1, taz, crb3, and vdr in familial and sporadic multiple sclerosis among an iranian population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/773a4cc80f744fb28ad2807b63ac856a
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Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population

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