“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes
Background: A pink color change occasionally found by us under magnifying endoscopy with narrow-band imaging (ME-NBI) may be a special feature of early gastric cancer (EGC), and was designated the “pink pattern”. The purposes of this study were to determine the relationship between the pink pattern...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:773e2f3df4ef40cab80f9475b3d2dd6f2021-11-15T05:33:32Z“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes2296-858X10.3389/fmed.2021.763675https://doaj.org/article/773e2f3df4ef40cab80f9475b3d2dd6f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.763675/fullhttps://doaj.org/toc/2296-858XBackground: A pink color change occasionally found by us under magnifying endoscopy with narrow-band imaging (ME-NBI) may be a special feature of early gastric cancer (EGC), and was designated the “pink pattern”. The purposes of this study were to determine the relationship between the pink pattern and the cytopathological changes in gastric cancer cells and whether the pink pattern is useful for the diagnosis of EGC.Methods: The color features of ME-NBI images and pathological images of cancerous gastric mucosal surfaces were extracted and quantified. The cosine similarity was calculated to evaluate the correlation between the pink pattern and the nucleus-to-cytoplasm ratio of cancerous epithelial cells. Two diagnostic tests were performed by 12 endoscopists using stored ME-NBI images of 185 gastric lesions to investigate the diagnostic efficacy of the pink pattern for EGC. The diagnostic values, such as the area under the curve (AUC), the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), of test 1 and test 2 were compared.Results: The cosine similarity between the color values of ME-NBI images and pathological images of 20 lesions was at least 0.744. The median AUC, accuracy, sensitivity, specificity, PPV, and NPV of test 2 were significantly better than those of test 1 for all endoscopists and for the junior and experienced groups.Conclusions: The pink pattern observed in ME-NBI images correlated strongly with the change in the nucleus-to-cytoplasm ratio of gastric epithelial cells, and could be considered a useful marker for the diagnosis of differentiated EGC.Shengsen ChenJiangping YuRongwei RuanYandong LiYali TaoQiwen ShenZhao CuiCheng ShenHuogen WangJiayan JinMing ChenChaohui JinShi WangFrontiers Media S.A.articlepink patternvessel-plus-surface classification systemearly gastric cancermagnifying endoscopyhistopathological changesMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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DOAJ |
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EN |
| topic |
pink pattern vessel-plus-surface classification system early gastric cancer magnifying endoscopy histopathological changes Medicine (General) R5-920 |
| spellingShingle |
pink pattern vessel-plus-surface classification system early gastric cancer magnifying endoscopy histopathological changes Medicine (General) R5-920 Shengsen Chen Jiangping Yu Rongwei Ruan Yandong Li Yali Tao Qiwen Shen Zhao Cui Cheng Shen Huogen Wang Jiayan Jin Ming Chen Chaohui Jin Shi Wang “Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| description |
Background: A pink color change occasionally found by us under magnifying endoscopy with narrow-band imaging (ME-NBI) may be a special feature of early gastric cancer (EGC), and was designated the “pink pattern”. The purposes of this study were to determine the relationship between the pink pattern and the cytopathological changes in gastric cancer cells and whether the pink pattern is useful for the diagnosis of EGC.Methods: The color features of ME-NBI images and pathological images of cancerous gastric mucosal surfaces were extracted and quantified. The cosine similarity was calculated to evaluate the correlation between the pink pattern and the nucleus-to-cytoplasm ratio of cancerous epithelial cells. Two diagnostic tests were performed by 12 endoscopists using stored ME-NBI images of 185 gastric lesions to investigate the diagnostic efficacy of the pink pattern for EGC. The diagnostic values, such as the area under the curve (AUC), the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), of test 1 and test 2 were compared.Results: The cosine similarity between the color values of ME-NBI images and pathological images of 20 lesions was at least 0.744. The median AUC, accuracy, sensitivity, specificity, PPV, and NPV of test 2 were significantly better than those of test 1 for all endoscopists and for the junior and experienced groups.Conclusions: The pink pattern observed in ME-NBI images correlated strongly with the change in the nucleus-to-cytoplasm ratio of gastric epithelial cells, and could be considered a useful marker for the diagnosis of differentiated EGC. |
| format |
article |
| author |
Shengsen Chen Jiangping Yu Rongwei Ruan Yandong Li Yali Tao Qiwen Shen Zhao Cui Cheng Shen Huogen Wang Jiayan Jin Ming Chen Chaohui Jin Shi Wang |
| author_facet |
Shengsen Chen Jiangping Yu Rongwei Ruan Yandong Li Yali Tao Qiwen Shen Zhao Cui Cheng Shen Huogen Wang Jiayan Jin Ming Chen Chaohui Jin Shi Wang |
| author_sort |
Shengsen Chen |
| title |
“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| title_short |
“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| title_full |
“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| title_fullStr |
“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| title_full_unstemmed |
“Pink Pattern” Visualized in Magnifying Endoscopy With Narrow-Band Imaging Is a Novel Feature of Early Differentiated Gastric Cancer: A Bridge Between Endoscopic Images and Histopathological Changes |
| title_sort |
“pink pattern” visualized in magnifying endoscopy with narrow-band imaging is a novel feature of early differentiated gastric cancer: a bridge between endoscopic images and histopathological changes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/773e2f3df4ef40cab80f9475b3d2dd6f |
| work_keys_str_mv |
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| _version_ |
1718428560069230592 |