Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion

Abstract Patients with tuberculous pleural effusion (TPE) or malignant pleural effusions (MPE) frequently have similar pleural fluid profiles. New biomarkers for the differential diagnosis of TPE are required. We determined whether cytokine profiles in the PE of patients could aid the differential d...

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Autores principales:	Neda Dalil Roofchayee, Majid Marjani, Neda K. Dezfuli, Payam Tabarsi, Afshin Moniri, Mohammad Varahram, Ian M. Adcock, Esmaeil Mortaz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/77415ce3851d45fca430221030ea6be0
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spelling	oai:doaj.org-article:77415ce3851d45fca430221030ea6be02021-12-02T14:01:24ZPotential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion10.1038/s41598-020-79685-12045-2322https://doaj.org/article/77415ce3851d45fca430221030ea6be02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79685-1https://doaj.org/toc/2045-2322Abstract Patients with tuberculous pleural effusion (TPE) or malignant pleural effusions (MPE) frequently have similar pleural fluid profiles. New biomarkers for the differential diagnosis of TPE are required. We determined whether cytokine profiles in the PE of patients could aid the differential diagnosis of TPE. 30 patients with TPE, 30 patients with MPE, 14 patients with empyema (EMP) and 14 patients with parapneumonic effusion (PPE) were enrolled between Dec 2018 and 2019. The levels of interleukin (IL)-6, IL-18, IL-27, CXCL8, CCL-1 and IP-10 were determined in PE by ELISA along with measurements of adenosine deaminase (ADA). The best predictors of TPE were combined ADA.IL-27 [optimal cut-off value = 42.68 (103 U ng/l2), sensitivity 100%, specificity 98.28%], ADA [cut off value 27.5 (IU/l), sensitivity 90%, specificity 96.5%] and IL-27 [cut-off value = 2363 (pg/ml), sensitivity 96.7%, specificity 98.3%, p ≤ 0.0001]. A high level of IL-6 [cut-off value = 3260 (pg/ml), sensitivity 100%, specificity 67.2%], CXCL8 [cut-off value = 144.5 (pg/ml), sensitivity 93.3%, specificity 58.6%], CCL1 [cut-off value = 54 (pg/ml), sensitivity 100%, specificity 70.7%] and IP-10 [cut-off value = 891.9 (pg/ml), sensitivity 83.3%, specificity 48.3%] were also predictive of TPE. High ADA.IL-27, ADA and IL-27 levels differentiate between TPE and non-TPE with improved specificity and diagnostic accuracy and may be useful clinically.Neda Dalil RoofchayeeMajid MarjaniNeda K. DezfuliPayam TabarsiAfshin MoniriMohammad VarahramIan M. AdcockEsmaeil MortazNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Neda Dalil Roofchayee Majid Marjani Neda K. Dezfuli Payam Tabarsi Afshin Moniri Mohammad Varahram Ian M. Adcock Esmaeil Mortaz Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
description	Abstract Patients with tuberculous pleural effusion (TPE) or malignant pleural effusions (MPE) frequently have similar pleural fluid profiles. New biomarkers for the differential diagnosis of TPE are required. We determined whether cytokine profiles in the PE of patients could aid the differential diagnosis of TPE. 30 patients with TPE, 30 patients with MPE, 14 patients with empyema (EMP) and 14 patients with parapneumonic effusion (PPE) were enrolled between Dec 2018 and 2019. The levels of interleukin (IL)-6, IL-18, IL-27, CXCL8, CCL-1 and IP-10 were determined in PE by ELISA along with measurements of adenosine deaminase (ADA). The best predictors of TPE were combined ADA.IL-27 [optimal cut-off value = 42.68 (103 U ng/l2), sensitivity 100%, specificity 98.28%], ADA [cut off value 27.5 (IU/l), sensitivity 90%, specificity 96.5%] and IL-27 [cut-off value = 2363 (pg/ml), sensitivity 96.7%, specificity 98.3%, p ≤ 0.0001]. A high level of IL-6 [cut-off value = 3260 (pg/ml), sensitivity 100%, specificity 67.2%], CXCL8 [cut-off value = 144.5 (pg/ml), sensitivity 93.3%, specificity 58.6%], CCL1 [cut-off value = 54 (pg/ml), sensitivity 100%, specificity 70.7%] and IP-10 [cut-off value = 891.9 (pg/ml), sensitivity 83.3%, specificity 48.3%] were also predictive of TPE. High ADA.IL-27, ADA and IL-27 levels differentiate between TPE and non-TPE with improved specificity and diagnostic accuracy and may be useful clinically.
format	article
author	Neda Dalil Roofchayee Majid Marjani Neda K. Dezfuli Payam Tabarsi Afshin Moniri Mohammad Varahram Ian M. Adcock Esmaeil Mortaz
author_facet	Neda Dalil Roofchayee Majid Marjani Neda K. Dezfuli Payam Tabarsi Afshin Moniri Mohammad Varahram Ian M. Adcock Esmaeil Mortaz
author_sort	Neda Dalil Roofchayee
title	Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
title_short	Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
title_full	Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
title_fullStr	Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
title_full_unstemmed	Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
title_sort	potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77415ce3851d45fca430221030ea6be0
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_version_	1718392148605272064

Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion

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