Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel di...

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Autores principales:	Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, Becca V. Baby, Bindu Hegde, Niranjan G. Kotla, Ankita A. Hiwale, Taslimarif Saiyed, Paresh Patel, Matam Vijay-Kumar, Morgan G. I. Langille, Gavin M. Douglas, Xi Cheng, Eric C. Rouchka, Sabine J. Waigel, Gerald W. Dryden, Houda Alatassi, Huang-Ge Zhang, Bodduluri Haribabu, Praveen K. Vemula, Venkatakrishna R. Jala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7744317287314ef5850cd0de51ff17e3
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spelling	oai:doaj.org-article:7744317287314ef5850cd0de51ff17e32021-12-02T14:39:37ZEnhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway10.1038/s41467-018-07859-72041-1723https://doaj.org/article/7744317287314ef5850cd0de51ff17e32019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07859-7https://doaj.org/toc/2041-1723Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.Rajbir SinghSandeep ChandrashekharappaSobha R. BodduluriBecca V. BabyBindu HegdeNiranjan G. KotlaAnkita A. HiwaleTaslimarif SaiyedParesh PatelMatam Vijay-KumarMorgan G. I. LangilleGavin M. DouglasXi ChengEric C. RouchkaSabine J. WaigelGerald W. DrydenHouda AlatassiHuang-Ge ZhangBodduluri HaribabuPraveen K. VemulaVenkatakrishna R. JalaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajbir Singh Sandeep Chandrashekharappa Sobha R. Bodduluri Becca V. Baby Bindu Hegde Niranjan G. Kotla Ankita A. Hiwale Taslimarif Saiyed Paresh Patel Matam Vijay-Kumar Morgan G. I. Langille Gavin M. Douglas Xi Cheng Eric C. Rouchka Sabine J. Waigel Gerald W. Dryden Houda Alatassi Huang-Ge Zhang Bodduluri Haribabu Praveen K. Vemula Venkatakrishna R. Jala Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
description	Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.
format	article
author	Rajbir Singh Sandeep Chandrashekharappa Sobha R. Bodduluri Becca V. Baby Bindu Hegde Niranjan G. Kotla Ankita A. Hiwale Taslimarif Saiyed Paresh Patel Matam Vijay-Kumar Morgan G. I. Langille Gavin M. Douglas Xi Cheng Eric C. Rouchka Sabine J. Waigel Gerald W. Dryden Houda Alatassi Huang-Ge Zhang Bodduluri Haribabu Praveen K. Vemula Venkatakrishna R. Jala
author_facet	Rajbir Singh Sandeep Chandrashekharappa Sobha R. Bodduluri Becca V. Baby Bindu Hegde Niranjan G. Kotla Ankita A. Hiwale Taslimarif Saiyed Paresh Patel Matam Vijay-Kumar Morgan G. I. Langille Gavin M. Douglas Xi Cheng Eric C. Rouchka Sabine J. Waigel Gerald W. Dryden Houda Alatassi Huang-Ge Zhang Bodduluri Haribabu Praveen K. Vemula Venkatakrishna R. Jala
author_sort	Rajbir Singh
title	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
title_short	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
title_full	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
title_fullStr	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
title_full_unstemmed	Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
title_sort	enhancement of the gut barrier integrity by a microbial metabolite through the nrf2 pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7744317287314ef5850cd0de51ff17e3
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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

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