A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associatio...
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Nature Portfolio
2021
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oai:doaj.org-article:7744806243e1477e9baddee9305b938e2021-12-02T14:01:15ZA comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization10.1038/s41467-020-20368-w2041-1723https://doaj.org/article/7744806243e1477e9baddee9305b938e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20368-whttps://doaj.org/toc/2041-1723Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.Jue-Sheng OngSuzanne C. Dixon-SuenXikun HanJiyuan AnEsophageal Cancer Consortium23 and Me Research TeamUpekha LiyanageJean-Cluade DusingizeJohannes SchumacherInes GockelAnne BöhmerJanusz JankowskiClaire PallesTracy O’MaraAmanda SpurdleMatthew H. LawMark M. IlesPaul PharoahAndrew BerchuckWei ZhengAaron P. ThriftCatherine OlsenRachel E. NealePuya GharahkhaniPenelope M. WebbStuart MacGregorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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Science Q Jue-Sheng Ong Suzanne C. Dixon-Suen Xikun Han Jiyuan An Esophageal Cancer Consortium 23 and Me Research Team Upekha Liyanage Jean-Cluade Dusingize Johannes Schumacher Ines Gockel Anne Böhmer Janusz Jankowski Claire Palles Tracy O’Mara Amanda Spurdle Matthew H. Law Mark M. Iles Paul Pharoah Andrew Berchuck Wei Zheng Aaron P. Thrift Catherine Olsen Rachel E. Neale Puya Gharahkhani Penelope M. Webb Stuart MacGregor A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| description |
Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers. |
| format |
article |
| author |
Jue-Sheng Ong Suzanne C. Dixon-Suen Xikun Han Jiyuan An Esophageal Cancer Consortium 23 and Me Research Team Upekha Liyanage Jean-Cluade Dusingize Johannes Schumacher Ines Gockel Anne Böhmer Janusz Jankowski Claire Palles Tracy O’Mara Amanda Spurdle Matthew H. Law Mark M. Iles Paul Pharoah Andrew Berchuck Wei Zheng Aaron P. Thrift Catherine Olsen Rachel E. Neale Puya Gharahkhani Penelope M. Webb Stuart MacGregor |
| author_facet |
Jue-Sheng Ong Suzanne C. Dixon-Suen Xikun Han Jiyuan An Esophageal Cancer Consortium 23 and Me Research Team Upekha Liyanage Jean-Cluade Dusingize Johannes Schumacher Ines Gockel Anne Böhmer Janusz Jankowski Claire Palles Tracy O’Mara Amanda Spurdle Matthew H. Law Mark M. Iles Paul Pharoah Andrew Berchuck Wei Zheng Aaron P. Thrift Catherine Olsen Rachel E. Neale Puya Gharahkhani Penelope M. Webb Stuart MacGregor |
| author_sort |
Jue-Sheng Ong |
| title |
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| title_short |
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| title_full |
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| title_fullStr |
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| title_full_unstemmed |
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| title_sort |
comprehensive re-assessment of the association between vitamin d and cancer susceptibility using mendelian randomization |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7744806243e1477e9baddee9305b938e |
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