The role of exercise on peripheral nerve regeneration: from animal model to clinical application
Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the incre...
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2021
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oai:doaj.org-article:77484b07ddbb4209938558bc7ec340f32021-12-02T05:02:25ZThe role of exercise on peripheral nerve regeneration: from animal model to clinical application2405-844010.1016/j.heliyon.2021.e08281https://doaj.org/article/77484b07ddbb4209938558bc7ec340f32021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023847https://doaj.org/toc/2405-8440Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the increase in knowledge of the mechanisms of injury and regeneration, a full functional recovery is still unsatisfying in the majority of patients. It is well known that exercise promotes physical and psychological well-being, by ameliorating general health. In the last years, there has been a growing interest in evaluating the effects of exercise on the peripheral nervous system. Experimental works with rodent models showed the potential utility of exercise following peripheral nerve injuries, as evinced by increasing axon regeneration, muscle reinnervation, better recovery of strength, muscle mass and higher expression of neurotrophic factors. Moreover, clinical evidence showed positive trends in favour of physical therapy following peripheral nerve damage based on the improvement of range of motion (ROM), muscle power grade and pain. After a brief overview of peripheral nerve anatomy and the different types of nerve injury, the present review aims to summarize the impact of exercise on peripheral nerve regeneration. Some clinical evidence regarding the effect of exercise after peripheral nerve injury will also be discussed.Grazia MaugeriVelia D'AgataBruno TrovatoFederico RoggioAlessandro CastorinaMichele VecchioMichelino Di RosaGiuseppe MusumeciElsevierarticleNerve injuryNerve regenerationPhysical exerciseTherapeutic exerciseScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08281- (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Nerve injury Nerve regeneration Physical exercise Therapeutic exercise Science (General) Q1-390 Social sciences (General) H1-99 |
| spellingShingle |
Nerve injury Nerve regeneration Physical exercise Therapeutic exercise Science (General) Q1-390 Social sciences (General) H1-99 Grazia Maugeri Velia D'Agata Bruno Trovato Federico Roggio Alessandro Castorina Michele Vecchio Michelino Di Rosa Giuseppe Musumeci The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| description |
Peripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the increase in knowledge of the mechanisms of injury and regeneration, a full functional recovery is still unsatisfying in the majority of patients. It is well known that exercise promotes physical and psychological well-being, by ameliorating general health. In the last years, there has been a growing interest in evaluating the effects of exercise on the peripheral nervous system. Experimental works with rodent models showed the potential utility of exercise following peripheral nerve injuries, as evinced by increasing axon regeneration, muscle reinnervation, better recovery of strength, muscle mass and higher expression of neurotrophic factors. Moreover, clinical evidence showed positive trends in favour of physical therapy following peripheral nerve damage based on the improvement of range of motion (ROM), muscle power grade and pain. After a brief overview of peripheral nerve anatomy and the different types of nerve injury, the present review aims to summarize the impact of exercise on peripheral nerve regeneration. Some clinical evidence regarding the effect of exercise after peripheral nerve injury will also be discussed. |
| format |
article |
| author |
Grazia Maugeri Velia D'Agata Bruno Trovato Federico Roggio Alessandro Castorina Michele Vecchio Michelino Di Rosa Giuseppe Musumeci |
| author_facet |
Grazia Maugeri Velia D'Agata Bruno Trovato Federico Roggio Alessandro Castorina Michele Vecchio Michelino Di Rosa Giuseppe Musumeci |
| author_sort |
Grazia Maugeri |
| title |
The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| title_short |
The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| title_full |
The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| title_fullStr |
The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| title_full_unstemmed |
The role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| title_sort |
role of exercise on peripheral nerve regeneration: from animal model to clinical application |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/77484b07ddbb4209938558bc7ec340f3 |
| work_keys_str_mv |
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